重组人CEACAM1蛋白-ACROBiosystems百普赛斯

Human CEACAM-1 / CD66a Protein, His Tag

分子别名（Synonym）

CEACAM1,CD66a,BGP,BGP1,BGPI

表达区间及表达系统（Source）

Human CEACAM-1, His Tag (CE1-H5220) is expressed from human 293 cells (HEK293). It contains AA Gln 35 - Gly 428 (Accession # AAH14473).

Predicted N-terminus: Gln 35

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 44.1 kDa. The protein migrates as 57-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to different glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>92% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

癌胚抗原相关细胞粘附分子1（CEACAM1）也称为胆汁糖蛋白1（BGP1），CD66a，属于免疫球蛋白超家族或CEA家族。CEACAM1/CD66a含有三个Ig样C2型（免疫球蛋白样）结构域和一个Ig样V型（免疫蛋白样）的结构域。CEACAM1/CD66a被描述为一种通过亲同和异亲方式介导细胞粘附的粘附分子，并在白细胞、上皮细胞和内皮细胞上检测到。研究表明，CEACAM1/BGP-1在多种细胞过程中发挥作用，包括组织分化、血管生成、凋亡、转移，以及调节先天性和适应性免疫反应。