阿霉素|T1456|TargetMol

Doxorubicin
23214-92-8

询价 500mg 起订

10mg 起订

50mg 起订

上海更新日期：2024-09-24

TargetMol中国（陶术生物）

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联系人：邵小姐

电话：021-021-33632979拨打

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邮箱：marketing@targetmol.com

产品详情:

中文名称：: 阿霉素

英文名称：: Doxorubicin

CAS号：: 23214-92-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

产品类别：: 抑制剂

货号：: T1456

Product Introduction

Bioactivity

Name	Doxorubicin
Description	Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
Cell Research	Doxorubicin is dissolved in stock solutions (1 mM) and serially diluted with RPMI 1640 media (0.1, 1, and 2 μM)[2]. 160 μL of Hela cells suspension (3×104 cell/mL) is dispensed into three 96-well U-bottom microplates and incubated for 24 h at 37°C in a fully humidified atmosphere of 5% CO2. In plate 1, serial dilutions of Doxorubicin (20 μL; final concentration, 0.1-2 μM) and Simvastatin (20 μL; final concentration, 0.25-2 μM) are added to a final volume of 200 μL and incubated for another 72 h. In plates 2 and 3 serial dilutions of each drug (Simvastatin or Doxorubicin, 40 μL) are added. After an incubation period of 24 h, the medium is aspirated and the cells are washed in PBS. Then, serial dilutions of other drug (40 μL) are added and supplemented with culture medium to a final volume of 200 μL, and incubated for 48 h. Doxorubicin and Simvastatin are used individually as positive controls (40 μL in each well), and the cells treated only with solvent are considered as negative controls. To evaluate cell survival, 20 μL of MTT solution (5 mg/mL in PBS) is added to each well and incubated for 3 h. Then the media is replaced with 150 μL of DMSO, and complete solubilization of formazan crystals is achieved by repeated pipetting of the solution. Absorbance is then determined at 540 nm by an ELISA plate reader. Each drug concentration is assayed in 4 or 8 wells and repeated 3 times. The cytotoxic/cytostatic effect of Doxorubicin is expressed as the relative viability (% control) and calculated. Percentage of cell survival in the negative control is assumed as 100. Relative viability=(experimental absorbance-background absorbance)/ (absorbance of untreated controls-background absorbance)×100 %[2].
In vitro	在高难度测试下（Doxorubicin为2 μM，Simvastatin为10 μM），Doxorubicin与Simvastatin的组合能够杀死97%的Hela细胞[2]。
In vivo	携带PC3异种移植瘤的小鼠分别被注射2、4或8 mg/kg的Doxorubicin，并随时间测量肿瘤体积。2 mg/kg的剂量对肿瘤生长无影响，而更高剂量初期可以延迟肿瘤生长（第18天和第22天时p<0.05），4 mg/kg或8 mg/kg的Doxorubicin显著降低PC3异种移植瘤中c-FLIP的水平[3]。在大鼠中，分别给予单次腹腔注射10 mg/kg（Doxorubicin 1）、连续10天每天腹腔注射1 mg/kg（Doxorubicin 2）或每周腹腔注射2 mg/kg共5次（Doxorubicin 3）。在Doxorubicin 1处理组中，第28天观察到80%的死亡率，而Doxorubicin 2和Doxorubicin 3分别在第107天和第98天达到80%死亡率。在第2周时，Doxorubicin 1导致的分数缩短降低了30%，在第13周Doxorubicin 2和Doxorubicin 3分别降低了55%和42%[4]。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : 50 mg/mL DMSO : 10 mM
Keywords	HIV \| Bacterial \| inhibit \| Antibiotic \| ADC Payload \| HBV \| Inhibitor \| AMP-activated protein kinase \| Topoisomerase \| Hepatitis B virus \| Apoptosis \| AMPK \| Doxorubicin \| Mitophagy \| Mitochondrial Autophagy \| Human immunodeficiency virus \| Autophagy \| ADC Cytotoxin
Inhibitors Related	Chitosan oligosaccharide \| Norfloxacin \| Metformin hydrochloride \| Methyl cinnamate

阿霉素|||Hydroxydaunorubicin|||DOX|||Adriamycin|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子