吡咯喹啉醌|T5692|TargetMol

Pyrroloquinoline quinone
72909-34-3

￥330 100mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

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联系人：邵小姐

电话：021-021-33632979拨打

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产品详情:

中文名称：: 吡咯喹啉醌

英文名称：: Pyrroloquinoline quinone

CAS号：: 72909-34-3

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: ≥95%

产品类别：: 抑制剂

货号：: T5692

Product Introduction

Bioactivity

名称	Pyrroloquinoline quinone
描述	Pyrroloquinoline quinone (PQQ), as a well-known redox enzyme cofactor, PQQ can protect NS/PCs against glutamate toxicity associated with ROS-mediated mitochondrial pathway,
动物实验	Healthy male Balb/C mice of 4–6 week were used to induce liver fibrosis and isolate primary HSCs.?The animals were obtained from SLAC Laboratory Animal Corp in SPF microbiological status.?All mice were maintained at 25°C with a 12 h dark/light cycle and completely randomly grouped.?For thioacetamide (TAA)-induced liver fibrosis, which has been shown to be closely resemble the panlobular and parenchymal fibrosis that is found in most human chronic liver disease , TAA was given by intraperitoneal injection ?at 200 mg/kg body weight 3 times each week for 8 weeks.?For bile duct ligation (BDL)-induced liver fibrosis, BDL was performed according to previous report , and mice were sacrificed 2 weeks later.?Administration of PQQ started on the second day when TAA was firstly given or BDL was performed, and PQQ was given at the dose of 0.3 mg/kg or 1 mg/kg by gastrogavage administration daily before mice were sacrificed.?Silymarin (150 mg/kg) was used as the positive control by gastrogavage administration daily.?Total number of 405 mice were used.?Mice were sacrificed by cervical dislocation under anesthesia[2].
体外活性	Pyrroloquinoline quinone（PQQ）预处理显示了其在保护NS/PCs免受谷氨酸诱导的凋亡/坏死中的显著效果。PQQ的神经保护作用与细胞内活性氧（ROS）产生的减少、谷胱甘肽（GSH）水平的增加以及caspase-3活性的降低有关。此外，PQQ预处理还显著提高了暴露于谷氨酸的NS/PCs中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的活性[1]。
体内活性	Pyrroloquinoline quinone(PQQ)，一种存在于多种人类食物中的天然抗氧化剂，在Balb/C小鼠的肝纤维化模型中显示出强大的抗纤维化和清除ROS活性。PQQ的抗氧化作用通过调节肝脏纤维化过程中多个步骤发挥作用，包括慢性肝损伤、肝脏炎症、肝星状细胞的激活以及细胞外基质的产生。PQQ还能在体内外抑制活化的HSCs中RACK1的上调。PQQ对于抑制小鼠的氧化应激和肝脏纤维化具有显著效果[2]。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 5 mg/mL (15.14 mM), Sonication is recommended. H2O : 0.2 mg/mL (0.61 mM), Sonication is recommended.
关键字	essential \| redox \| Endogenous Metabolite \| anionic \| inhibit \| Pyrroloquinoline quinone \| Methoxatin \| co-factor \| PQQ \| bacteria \| function \| methylotropic \| immune \| nutrient \| Inhibitor
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吡咯喹啉醌|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子