N'-硝基-L-精氨酸甲酯盐酸盐|T6570|TargetMol

L-NAME hydrochloride
51298-62-5

￥418 100mg 起订

￥756 500mg 起订

￥298 50mg 起订

上海更新日期：2025-10-31

TargetMol中国（陶术生物）

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产品详情:

中文名称：: N'-硝基-L-精氨酸甲酯盐酸盐

英文名称：: L-NAME hydrochloride

CAS号：: 51298-62-5

品牌：: TargetMol

产地：: 美国

保存条件：: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.93%

产品类别：: 抑制剂

货号：: T6570

Product Introduction

Bioactivity

名称	L-NAME hydrochloride
描述	L-NAME hydrochloride is an inhibitor of nitric oxide synthase (NOS) with an IC₅₀ of 70 μM, and it can be used to induce hypertension and kidney injury models.
细胞实验	rMC-1 cells are incubated in 5 or 25 mM glucose, with or without l-NAME (1 mM). Media is changed every other day for up to 5 days. BREC cells are incubated in 5 or 25 mM glucose as well as inhibitor as described above for 5 days. Cell death is determined by light microscopy using a hemocytometer and a 0.4% trypan blue dye exclusion method. The number of cells that do not exclude the dye is expressed per 1,000 total cells. A minimum of 800 cells is counted per assay (8 dishes, >100 cells counted per dish), and the assay is replicated three times on different days. (Only for Reference)
激酶实验	Enzyme Assay: The oxidation of L-arginine is monitored by the conversion of [3H]- or [14C]-arginine to L-citrulline which separates L-citrulline from L-arginine by Dowex 50x8-200 (Na) chromatography. Typical reaction mixtures (100 pL) contains 50 mM HEPES, pH 7.0, 8 pM tetrahydrobiopterin, 1 mM CaC12, 0.01 mg/mL calmodulin, 0.5 mM EDTA, 0.450 pM [14C]-arginine (30000 cpm), and 100-200 pM NADPH. The cNOS-catalyzed oxidation of NADPH to NADP+ is monitored by the reduction of absorbance at 340 nm with a Kontron 860 spectrophotometer in a volume of 300 pL. All reactions are at 30 ℃ unless otherwise indicated.
体内活性	L-NAME（0.03-300 mg kg-1，静脉注射）会导致剂量依赖性的平均系统动脉血压增加，伴随心动过缓现象。L-NAME（100 mg kg-1，静脉注射）显著抑制了对乙酰胆碱和缓激肽的低血压反应。L-NAME引起的血压增加和心动过缓可以通过L-精氨酸（30-100 mg kg-1，静脉注射）以剂量依赖方式逆转。[2]
存储条件	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 250 mg/mL (926.99 mM), Sonication is recommended. H2O : 27 mg/mL (100.11 mM), Sonication is recommended.
关键字	NOSynthase \| NOS \| NO Synthase \| nNOS \| Nitric oxide synthases \| NG-Nitroarginine methyl ester Hydrochloride \| NG-Nitroarginine methyl ester \| L-NAME Hydrochloride \| LNAME hydrochloride \| L-NAME \| L NAME hydrochloride \| iNOS \| Inhibitor \| inhibit \| eNOS
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N'-硝基-L-精氨酸甲酯盐酸盐|||NG-Nitroarginine methyl ester hydrochloride|||N(G)-Nitro-L-arginine methyl ester|||L-NAME HCl|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(13年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子