鼠尾草酸|T4957|TargetMol

Carnosic acid
3650-09-7

￥269 5mg 起订

￥391 10mg 起订

￥773 25mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 鼠尾草酸

英文名称：: Carnosic acid

CAS号：: 3650-09-7

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.5%

产品类别：: 抑制剂

货号：: T4957

Product Introduction

Bioactivity

名称	Carnosic acid
描述	Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
细胞实验	Human dopaminergic neuroblastoma SH-SY5Y cells were cultured in Dulbecco's modified Eagle's medium (DMEM)/F-12 HAM nutrient medium (1:1 mixture; supplemented with 10% fetal bovine serum (FBS), 2 mM L-glutamine, penicillin (1000 units/mL), streptomycin (1000 μg/mL), and amphotericin B (2.5 μg/mL)) in a 5% CO2 humidified incubator at 37 °C. SH-SY5Y cells were cultured until a confluence of 80–90% was achieved and then trypsinized. H2O2 was utilized at 300 μM for different periods of incubation according to each specific assay. A pretreatment with CA (dissolved in DMSO) at 1 μM for 12 h was performed in order to test the ability of this diterpene in preventing the deleterious effects triggered by H2O2 in SH-SY5Y cells [2].
动物实验	Male C57BL/KsJ-db/db mice were given an intradermal injection of 100 μg of chicken type II collagen emulsified in complete Freund's adjuvant (1:1, w/v) into the base of the tail. 18 days after primary immunization, all mice showed signs of arthritis, and a booster, which consisted of 100 μg of chicken type II collagen emulsified in incomplete Freund's adjuvant (IFA; 1:1, v/v), was injected intradermally. All mice were divided into 7 groups; normal (Nor), db/db, db/db/CIA, and db/db/CIA with CA treatment. To investigate the effects of Carnosic acid (CA) on the development of arthritis, db/db mice and db/db/CIA mice were treated with 30 mg/kg body weight CA (CAL) and 60 mg/kg body weight CA (CAH) seven times per week for 4 weeks intraperitoneally after the booster injection. CA was prepared as 10 mmol/L stock solutions in DMSO [3].
体外活性	ARPE-19细胞先用10 μM的Carnosic acid预处理24小时，然后用丙烯酰胺（0.7或1 mM）处理24小时。与仅用丙烯酰胺处理的ARPE-19细胞相比，先用10 μMCarnosic acid预处理的ARPE-19细胞显示出明显增加的细胞活力和降低的细胞死亡率[1]。人类神经母细胞瘤SH-SY5Y细胞用1 μM的Carnosic acid预处理12小时，可防止过氧化氢（H2O2）引起的TCA酶（异柠檬酸酶、α-酮戊二酸脱氢酶（α-KGDH）、琥珀酸脱氢酶（SDH））功能受损，并消除了复合体I和V的抑制，并通过与Nrf2相关的机制恢复了ATP水平[2]。
体内活性	肉豆蔻酸显著下调空腹血糖水平、口服葡萄糖耐量试验(OGTT)和胰岛素耐量试验(ITT)中的葡萄糖水平，改善了CIA诱导的骨质流失，并在CIA诱导的db/db小鼠关节炎模型中减少了促炎细胞因子和活性氧(ROS)的生成[3]。
存储条件	keep away from direct sunlight,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 100 mg/mL (300.82 mM) H2O : Insoluble
关键字	Inhibitor \| inhibit \| Carnosic acid \| Bacterial \| Apoptosis
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鼠尾草酸|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子