茶黄素|T7602|TargetMol

Theaflavin
4670-05-7

￥283 1mg 起订

￥648 5mg 起订

￥950 10mg 起订

上海更新日期：2024-09-24

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 茶黄素

英文名称：: Theaflavin

CAS号：: 4670-05-7

品牌：: TargetMol

产地：: 美国

保存条件：: store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.28%

产品类别：: 抑制剂

货号：: T7602

Product Introduction

Bioactivity

Name	Theaflavin
Description	Theaflavin is a polyphenolic flavonoid that has been found in black tea and has diverse biological activities, including antioxidant, anticancer, anti-inflammatory, and antiviral properties
Cell Research	Cell proliferation assay, Hoechst 33342 staining assay, Caspase-Glo Assay, western blot, human umbilical vein endothelial cell tube formation assay and vascular endothelial growth factor (VEGF) enzyme-linked immunosorbent assay were performed[1].
Animal Research	ICH rat models were induced with type VII collagenase and pretreated with TF by gavage in different doses (25 mg/kg-100 mg/kg).?Twenty-four hours after ICH attack, evaluated the rats' behavioral performance, the blood-brain barrier (BBB) integrity, and the formation of cerebral edema.?The levels of reactive oxygen species (ROS) and inflammatory cytokines were examined by 2',7'-dichlorofluorescin diacetate and enzyme-linked immunosorbent assay.?Nissl staining and transferase dUTP nick end labeling (TUNEL) were aimed to detect the neuron loss and apoptosis, the mechanism of which was explored by Western blot[2].
In vitro	Theaflavin 抑制OVCAR-3 和 A2780/CP70 人类卵巢癌细胞系的生长，但对卵巢上皮细胞系IOSE 364 不产生抑制作用（IC50 分别为11.9、38.5 和 >40 μM）[1]。
In vivo	在预处理的ICH大鼠中，Theaflavin显著缓解了行为缺陷，保护了血脑屏障（BBB）的完整性，减少了脑水肿的形成和活性氧（ROS）以及炎症细胞因子（包括白细胞介素-1β[IL-1β]、IL-18、肿瘤坏死因子-α、干扰素-γ、转化生长因子β和(C-X-C基序)配体1[CXCL1]）的水平。Nissl染色和TUNEL实验显示，Theaflavin通过抑制核转录因子kappa-β-p65（NF-κβ-p65）、caspase-1和IL-1β[2]的激活，保护神经细胞免受损失和凋亡。
Storage	store at low temperature,keep away from direct sunlight,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 5.65 mg/mL (10 mM), Sonication is recommended.
Keywords	Endogenous Metabolite \| inhibit \| Theaflavin \| Influenza Virus \| Inhibitor
Inhibitors Related	Formamide \| Guanidine hydrochloride \| Naringin \| Oleic acid \| Daidzein \| Vanillin \| Glycerol \| Sucrose \| Ferulic Acid \| 3-Indoleacetic acid \| Thymidine \| Fumaric acid
Related Compound Libraries	Bioactive Compound Library \| Bioactive Compounds Library Max \| Ancient Chinese Classical Formulas Compound Library \| Anti-Tumor Natural Product Library \| Anti-Viral Compound Library \| Anti-virus Traditional Chinese Medicine Monomer Library \| Anti-Inflammatory Traditional Chinese Medicine Compound Library \| Natural Product Library for HTS \| Anti-infective Natural Product Library

茶黄素|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子