曲酸|T5889|TargetMol

Kojic acid
501-30-4

￥122 500mg 起订

上海更新日期：2026-01-06

TargetMol中国（陶术生物）

VIP13年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 曲酸

英文名称：: Kojic acid

CAS号：: 501-30-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.72%

产品类别：: 抑制剂

货号：: T5889

Product Introduction

Bioactivity

名称	Kojic acid
描述	Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 μM for mushroom tyrosinase.
细胞实验	Amazonensis promastigotes (10^6 parasites/mL) were inoculated in a 24-well plate containing RPMI medium supplemented with 10% inactivated fetal bovine serum treated with different concentrations of KA and incubated at 25 °C for 5 days without medium replacement. Every 24 h after treatment, aliquots were harvested and the effect of Kojic acid on promastigotes growth was evaluated using a Neubauer chamber and compared with untreated parasites culture. The cultures were performed in triplicate[1].
动物实验	Animals (eight-week-old female Golden hamsters) were infected with 10^6 of L. amazonensis promastigotes/mL during the stationary growth phase with a maximum volume of 0.2 mL on both hind paws.?Animals were separated in 3 groups: untreated (n?=?5);?KA-treated 100 mg/kg/day (n?=?5) and KA vehicle (n?=?5).?KA topical formulation treatment was initiated after 5 weeks of infection.?The KA formulation and vehicle was applied topically to all lesions once daily for 4 weeks.?Control groups were also maintained in parallel.?During the treatment period, the lesion size was measured weekly using a caliper.?Width and height of both hind paws were used to calculate the lesion area (mm^2)[1].
体外活性	Kojic acid（KA）（50 μg/mL）在体外实验中，分别减少了promastigotes和amastigotes生长62%（IC50 34 μg/mL）和79%（IC50 27.84 μg/mL）。KA处理后的amastigotes表现出鞭毛囊内有囊泡体出现，以及线粒体内部出现明显的液泡化和肿胀。在寄生虫与宿主细胞的体外相互作用中，KA能逆转由寄生虫促进的超氧阴离子（O2-）的抑制机制。
体内活性	在KA局部涂故治疗感染动物4周后，观察到一个愈合过程，其特点是胶原纤维的高产生以及寄生虫负担的减少。这展示了KA作为抗利什曼病化合物的巨大潜力[1]。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 158.33 mg/mL (1114.14 mM), Sonication is recommended.
关键字	tyrosinase \| Parasite \| Kojic acid \| Inhibitor \| inhibit
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曲酸|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(13年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子