氯硝柳胺|T0711|TargetMol

Niclosamide
50-65-7

￥320 500mg 起订

上海更新日期：2026-05-08

TargetMol中国（陶术生物）

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电话：021-021-33632979拨打

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产品详情:

中文名称：: 氯硝柳胺

英文名称：: Niclosamide

CAS号：: 50-65-7

品牌：: TargetMol

产地：: 美国

保存条件：: Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 98.47%

产品类别：: 抑制剂

货号：: T001|T0711

Product Introduction

Bioactivity

名称	Niclosamide
描述	Niclosamide is a classic salicylanilide antiparasitic drug and a multi-target, low-toxicity, broad-spectrum small-molecule modulator with anthelmintic and antitumor activity. Niclosamide disrupts the parasite’s energy metabolism by uncoupling mitochondrial oxidative phosphorylation, leading to reduced ATP production and ultimately killing the parasite. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells.
细胞实验	Cells are plated in 96-well culture plates with cell density of 3-4 × 103 cells/well and treat with Niclosamide by adding 100 μL medium containing Niclosamide of various concentrations on the second day. After 72-hour's treatment, MTT is added to each well and incubated for additional 4-5 hours, and the absorbance is measured on a microplate reader at 570 nM. Cell growth inhibition is evaluated as the ratio of the absorbance of the sample to that of the control. The results are representative of at least 3 independent experiments. (Only for Reference)
激酶实验	Protein Kinase profiling assay: Assay for 22 different proteins kinases is carried out by ProQinase Gmbh. All of the protein kinases are expressed either in Sf9 insect cells or in E.coli as recombinant GST-fusion proteins or His-tagged proteins. Protein kinases are purified by affinity chromatography using either GSH-agarose or Ni_NTH-agarose. A radiometric protein kinase assay is used for measuring the kinase activity of the 22 protein kinases. Briefly, for each protein kinase, 50 μL reaction cocktail containing 60 mM HEPES-NaOH, 3 mM MgCl2, 3 mM MnCl2, 3 μM Na-orthovanadate, 1.2 mM DTT, 50 μg/mL PEG20000, 1 μM [γ-33P]-ATP, Niclosamide, adequate amount of enzyme and its substrate. The PKC-alpha assay additionally contain 1 mM Cacl2, 4 mM EDTA, 5 μg/mL phosphatidylserine and 1 μg/mL 1, 2-Dioleyl-glycerol. The reaction cocktails are incubated at 37 °C for 60 minutes and stop with 50 μL 2% (v/v) H3PO4. Incorporation of 33Pi is determined with a microplate scintillation counter. The activities and the IC50 values are calculated using Quattro Workflow V2.28.
体外活性	方法：从 MDA-MB-231 细胞中分离的 CD44⁺/CD24⁻ 乳腺癌干细胞（CSCs）加入 Niclosamide （100 μM），处理 6 小时，Western blot 检测 p-STAT3， STAT3， Bax 蛋白水平。结果：Niclosamide 诱导 p-STAT3 水平显著降低，促凋亡蛋白 Bax 水平显著升高。[1]
体内活性	方法：13 周龄雄性 SOD1-G93A 小鼠腹腔注射 Niclosamide (20 mg/kg 或 50 mg/kg)，每日一次，直至终末期(约 160 天)。结果：20 mg/kg Niclosamide 效果显著，改善神经学评分，延缓运动功能衰退，显著延长生存期，提高疾病各阶段的生存概率。[2] 方法：雄性 db/db 小鼠(2 型糖尿病模型)，所有小鼠在 8 周龄时行右侧肾切除术以加速 DN 发展，手术后腹腔注射 Niclosamide (20 mg/kg/天)，每日一次，连续 4 周。结果：Niclosamide 显著降低血糖和 HbA1c，减少尿量，改善 BUN 和 Cr，并阻止了尿白蛋白的进行性增加，减轻肾脏肥大、肾小球硬化、系膜扩张和 Col-IV 沉积；恢复 nephrin 表达和足细胞数量。[3]
存储条件	Keep away from moisture Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 0.63 mg/mL (1.93 mM), Solution. DMSO : 6.25 mg/mL (19.11 mM), Sonication is recommended.
关键字	Vero E6 \| SW-13 \| STAT3 \| STAT \| Parasite \| Niclosamide \| NCI-H295R \| Inhibitor \| inhibit \| Hela \| BD140A \| bayluscide \| BAY-2353 \| BAY 2353 \| antihelminthic \| Antibiotic
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氯硝柳胺;Niclocide;BAY2353;TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(14年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子