重组人CCR8蛋白, Flag,His Tag&Twin-Strep Tag (Detergent)

Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Detergent)

分子别名（Synonym）

CC chemokine receptor 8,CD198,ChemR1,CKRL1,CKR-L1,CKRL1,CY6,GPRCL1,GPRCY6,GPR-CY6,TER-1

表达区间及表达系统（Source）

Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (CC8-H52D6) is expressed from human 293 cells (HEK293). It is a membrane protein, contains complete wild type 7-transmembrane domans (TMD) and extracellular doman (ECD).

Predicted N-terminus: N/A

蛋白结构（Molecular Characterization）

This protein carries a Flag tag at the N-terminus, and a polyhistidine tag at the C-terminus, followed by a twin strep tag. The protein has a calculated MW of 62.0 kDa.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

由于洗涤剂的细胞毒性，该产品不适合基于细胞的实验。

洗涤剂缓冲液无法保持膜蛋白的可溶性和活性，在任何情况下都不应该去除洗涤剂。

洗涤剂缓冲液单独出售，不包含在蛋白质中，如果您需要缓冲液，请与我们联系。

如果甘油与您的应用不兼容，请在实验前立即去除甘油，切勿储存无甘油的蛋白质溶液。

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, Buffer B, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 3 months under sterile conditions.

背景（Background）

This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs). CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine). It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.