PE-Labeled Human B7-H3 / CD276 Protein, His Tag

PE-Labeled Human B7-H3 / CD276 Protein, His Tag

分子别名（Synonym）

B7-H3,CD276,B7 homolog 3

表达区间及表达系统（Source）

PE-Labeled Human B7-H3 Protein, His Tag (B73-HP2H3) is expressed from human 293 cells (HEK293). It contains AA Leu 29 - Pro 245 (Accession # Q5ZPR3-2).

Predicted N-terminus: Leu 29

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 37.6 kDa.

偶联（Conjugate）

PE

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 0.2% BSA, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 12 months under sterile conditions after reconstitution.

背景（Background）

B7同源物3（B7-H3）是免疫球蛋白超家族的成员，也被称为CD276，它包含两个Ig样C2型（免疫球蛋白样）结构域和两个Ig型V型（免疫蛋白样）的结构域。B7-H3可能参与调节T细胞介导的免疫反应。B7-H3还通过抑制自然杀伤介导的细胞裂解在肿瘤细胞中发挥保护作用，并作为检测神经母细胞瘤细胞的标志物。此外，B7-H3参与急性和慢性移植排斥反应的发展以及粘膜表面淋巴细胞活性的调节。它还可以在整个怀孕期间为胎盘和胎儿提供合适的免疫环境方面发挥关键作用。