小鼠MERTK蛋白-ACROBiosystems百普赛斯

Mouse MERTK / Mer Protein, His Tag (MALS verified)

分子别名（Synonym）

MERTK,Mer

表达区间及表达系统（Source）

Mouse MERTK, His Tag (MEK-M52H9) is expressed from human 293 cells (HEK293). It contains AA Gly 19 - Met 497 (Accession # Q60805-1).

Predicted N-terminus: Gly 19

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 54.2 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 3 months under sterile conditions.

背景（Background）

酪氨酸蛋白激酶Mer（MERTK）是TYRO3/AXL/Mer（TAM）受体激酶家族的成员，编码一种跨膜蛋白，具有两个纤维连接蛋白III型结构域、两个Ig样C2型（免疫球蛋白样）结构域和一个酪氨酸激酶结构域。在配体激活后，与GRB2或PLCG2相互作用，诱导MAPK1、MAPK2、FAK/PTK2或RAC1的磷酸化。MERTK信号在巨噬细胞清除凋亡细胞、血小板聚集、细胞骨架重组和吞噬等各种过程中起着重要作用。视网膜色素上皮（RPE）作为杆状外节片段吞噬作用的调节因子。通过激活STAT1，在抑制Toll样受体（TLRs）介导的先天免疫反应中也起着重要作用，STAT1选择性诱导细胞因子信号SOCS1和SOCS3抑制剂的产生。