小鼠ADAM9蛋白-ACROBiosystems百普赛斯

Mouse ADAM9 Protein, His Tag (active enzyme, MALS verified)

分子别名（Synonym）

Disintegrin and metalloproteinase domain-containing protein 9 (EC:3.4.24.-) Cellular disintegrin-related protein,Meltrin-gamma,Metalloprotease,disintegrin,cysteine-rich protein 9,Myeloma cell metalloproteinase,ADAM9,KIAA0021, MCMP, MDC9, MLTNG

表达区间及表达系统（Source）

Mouse ADAM9, His Tag (AD9-M52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 206 - Asp 697 (Accession # Q61072).

Predicted N-terminus: Ala 206

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 55.2 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

制剂（Formulation）

Supplied as 0.2 μm filtered solution in 25mM MES,150mM NaCl,pH6.0 with glycerol as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

ADAM9（去整合素和金属蛋白酶9）是一种膜锚定蛋白，主要通过用于粘附的去整合素结构域和用于多种细胞表面蛋白胞外区脱落的金属蛋白酶结构域参与多种生理功能。ADAM9影响发育过程、炎症和退行性疾病。最近，越来越多的证据表明ADAM9在肿瘤生物学中起着重要作用。在几种癌症类型中发现了ADAM9的过度表达，并与肿瘤进展和不良预后相关。此外，通过蛋白水解或非蛋白水解途径，ADAM9促进肿瘤进展、治疗耐药性和癌症转移。因此，全面了解ADAM9的作用机制对于开发治疗性抗癌策略至关重要。在这篇综述中，我们总结了ADAM9在生物学功能、病理生理疾病和各种癌症中的最新认识。还介绍了使用ADAM9相关途径的治疗策略的最新进展。