小鼠LRP-6蛋白-ACROBiosystems百普赛斯

Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag

分子别名（Synonym）

LRP-6,LRP6

表达区间及表达系统（Source）

Human LRP-6 (20-630), Mouse IgG2a Fc Tag (LR6-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 630 (Accession # O75581-1  ).

Predicted N-terminus: Ala 20

蛋白结构（Molecular Characterization）

This protein carries a mouse IgG2a Fc tag at the C-terminus.

The protein has a calculated MW of 95.8 kDa. The protein migrates as 55 kDa and 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

LRP6是一种跨膜低密度脂蛋白受体，与LRP5具有相似的结构。低密度脂蛋白受体相关蛋白6是参与经典Wnt通路的LRP5/LRP6/卷曲共受体组的关键组成部分。Wnt诱导的Fzd/LRP6共受体复合物将DVL1聚合物募集到质膜，进而将AXIN1/GSK3B复合物募集到细胞表面，促进信号体的形成，抑制AXIN1/葛兰素史克介导的β-连环蛋白的磷酸化和破坏。