小鼠IL-6蛋白-ACROBiosystems百普赛斯

Mouse IL-6 Protein, His Tag

分子别名（Synonym）

IL6,Interleukin-6,BSF2,HSF,IFNB2

表达区间及表达系统（Source）

Mouse IL-6, His Tag (IL6-M5245) is expressed from human 293 cells (HEK293). It contains AA Phe 25 - Thr 211 (Accession # P08505-1).

Predicted N-terminus: His

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 23.6 kDa. The protein migrates as 25-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

白细胞介素6（IL-6）也称为HGF、BSF2、HSF、IFNB2和IL-6，最初被鉴定为B细胞分化因子，是一种调节免疫反应、造血、急性期反应和炎症反应的多功能细胞因子。它由T细胞、巨噬细胞、单核细胞、成纤维细胞、内皮细胞等分泌，以刺激对创伤的免疫反应，特别是烧伤或其他导致炎症的组织损伤。白介素6已被证明与白介素-6受体和糖蛋白相互作用。IL-6与许多疾病过程有关，如糖尿病、动脉粥样硬化、抑郁症、阿尔茨海默病、系统性红斑狼疮、前列腺癌症和类风湿性关节炎。晚期/转移性癌症患者血液中的IL-6水平较高。因此，人们有兴趣开发抗IL-6药物作为治疗许多这些疾病的方法。