免疫显性表位多肽/444305-16-2/Myelin Basic Protein (85-99) peptide antagonist

Product Name：Myelin Basic Protein (85-99) peptide antagonist

CAS No.：444305-16-2

Synonyms：免疫显性表位多肽

Catalog No.：176P06

Brand：HongTide（上海鸿肽生物）

Description：Myelin Basic Protein (85-99) peptide antagonist是拮抗性多肽与 MBP (85-99) 竞争，MBP (85-99) 是髓鞘碱性蛋白 (MBP) 的免疫显性表位，是多发性硬化症 (MS) 中的主要候选自身抗原，与人类白细胞抗原 (HLA)-DR2 结合，是由15个氨基酸组成的多肽。该肽还抑制 MBP (85-99) 特异性 T 细胞克隆分泌 IL-2 并诱导脾细胞产生 Th2 细胞因子。 此外，可以证明该肽能够以与无规氨基酸共聚物（例如 Copaxone [poly (Y,E,A,K)n] 等随机氨基酸共聚物等效的方式）在几种模型中抑制实验性自身免疫性脑脊髓炎 (EAE) . 因此，这种合成肽可能适用于 MS 的研究。

Myelin Basic Protein (85-99) peptide antagonist is an antagonistic peptide that competes with MBP (85-99), which is an immune dominant epitope of myelin basic protein (MBP) and a major candidate self antigen in multiple sclerosis (MS). It binds to human leukocyte antigen (HLA) - DR2 and is a peptide composed of 15 amino acids. This peptide also inhibits the secretion of IL-2 by MBP (85-99) - specific T cell clones and induces the production of Th2 cytokines by spleen cells. In addition, it can be demonstrated that the peptide can inhibit experimental autoimmune encephalomyelitis (EAE) in several models in an equivalent manner to random amino acid copolymers such as Copaxone [poly (Y, E, A, K) n]. Therefore, this synthetic peptide may be suitable for the study of MS.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

上海鸿肽生物科技有限公司

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邮箱：sales1@hongtide.com

本产品仅供科研使用。