阿魏酸甲酯|TL0004|TargetMol

FERULIC ACID METHYL ESTER
2309-07-1

￥99 50mg 起订

上海更新日期：2024-09-23

TargetMol中国（陶术生物）

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联系人：邵小姐

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产品详情:

中文名称：: 阿魏酸甲酯

英文名称：: FERULIC ACID METHYL ESTER

CAS号：: 2309-07-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.87%

产品类别：: 抑制剂

货号：: TL0004

Product Introduction

Bioactivity

名称	FERULIC ACID METHYL ESTER
描述	FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid methyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.
细胞实验	Hydrogen peroxide (8.8 M solution) stored at 4 C was firstdiluted in PBS to prepare a 100 mM solution on the day of theexperiment. This was further diluted in growth medium to preparethe final working solution. PC12 cells were plated in collagencoated96-well microplates at a density of 5 105 cells/ml(100 μl per well). Blank wells contained only growth medium forbackground correction. After 48 h of incubation to allow for cellattachment, 20 μl of growth medium supplemented with differentconcentrations of HCAs were added in triplicate wells and preincubatedfor 1 h. Maximum concentration of DMSO in the wellswas kept below 0.2%. Afterwards, 20 μl of H2O2 solution was added.The concentration of H2O2 in the well was 75 μM. After anotherhour, the medium was replaced with fresh one and cells wereincubated overnight. In the end, the medium was replaced with30 μl of MTT 0.5 mg/ml dissolved in RPMI without phenol red.Formazan crystals were solubilised in 200 μl DMSO after 1.5 h ofincubation at 37 C.
激酶实验	DPPH radical scavenging activity of caffeic acid and ferulic acid derivatives was assessed as previously described withsome modifications. Briefly, the test compound was dissolved in dimethyl sulfoxide and 4 different concentrations weremixed with a methanolic solution of DPPH 100 mM in duplicate. After 30 min of incubation at room temperature in the dark, theabsorbance at 517 nm was measured by a spectrophotometer . The concentrations (in the range 1-100 μM) were carefully chosen for each compound in order to produce a suitable doseeresponse curve. The percent inhibition of the radical was calculated based on the absorbance of the mixture compared to the absorbance of DPPH solution alone.
体外活性	FERULIC ACID METHYL ESTER的抗氧化能力不如阿魏酸在神经PC12细胞中的表现（IC50值：阿魏酸乙酯为74.7 μM，而阿魏酸为44.6 μM，通过2,2-二苯基-1-吡啶肼自由基清除作用衡量）。在10-25 μg/ml的浓度下，FERULIC ACID METHYL ESTER能够抑制炎症反应，具体表现为抑制脂多糖（LPS）激活的巨噬细胞产生的促炎细胞因子的释放，阻止环氧合酶-2（COX-2）的表达，以及减少一氧化氮的生成。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 50 mg/mL (240.14 mM) Ethanol : 20 mg/mL
关键字	Inhibitor \| inhibit \| FERULIC ACID METHYL ESTER \| p38 MAPK \| Autophagy
相关产品	Guanidine hydrochloride \| Naringin \| Valproic Acid \| Taurine \| Gefitinib \| Aceglutamide \| Hydroxychloroquine \| Curcumin \| Stavudine \| Salicylic acid \| Paeonol \| Sodium 4-phenylbutyrate
相关库	经典已知活性库 \| 已知活性化合物库 \| 古代经典名方目录分子库 \| 激酶抑制剂库 \| 抗衰老化合物库 \| 抗癌天然产物库 \| 中药单体化合物库 \| 天然产物库 \| 烟草单体化合物库 \| 中药抗炎分子库

阿魏酸甲酯|||Methyl ferulate|||Methyl 4'-hydroxy-3'-methoxycinnamate|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子