化合物 ZM 336372|T1851|TargetMol

ZM 336372
208260-29-1

￥261 2mg 起订

￥446 5mg 起订

￥789 10mg 起订

上海更新日期：2024-09-23

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 化合物 ZM 336372

英文名称：: ZM 336372

CAS号：: 208260-29-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 97.51%

产品类别：: 抑制剂

货号：: T1851

Product Introduction

Bioactivity

Name	ZM 336372
Description	ZM 336372 is a potent and selective c-Raf inhibitor.
Cell Research	Cells are exposed to various concentrations of ZM 336372 for 48 and 72 hours. After incubation, the medium is removed and cells are trypsinized. Cells are incubated on ice, and 2.5 μg/mL propidium iodide is added 5 minutes before flow cytometry. Data is acquired using a FACSCalibur benchtop flow cytometer using CellQuest acquisition and analysis software. Cytotoxicity is done using Cell Titer Glo Assay. Cell proliferation is measured using MTT assay.(Only for Reference)
Kinase Assay	In vitro kinase assay: c-Raf kinase activity is assayed directly in Sl9 cell lysates. Human c-Raf is activated in Sf9 cells by cotransfection from baculovirus vectors containing DNA encoding v-Ras and Lck in the absence of ZM 336372. The cell lysates are then assayed for c-Raf activity in the presence of increasing concentrations of ZM 336372.
In vivo	1 μM ZM 336372消除过氧化氢处理后eNOS的上调。ZM 336372在HepG2中以剂量依赖性方式诱导抑制增殖,抑制激素分泌和上调细胞周期抑制剂。ZM 336372作用于C-Raf 的选择性是作用于B-Raf的10倍。ZM 336372抑制嗜铬细胞瘤细胞的增殖,并抑制NE血管活性肽产生。ZM 336372微弱抑制SAPK2a/p38α和SAPK2b/p38β,IC50 为2 μM,即使在高达50 μM浓度下,对C-Raf的选择性也高于包括PKA,PKC,AMPK,p42 MAPK,MKK1,SAPK1/JNK和CDK1等17种其他蛋白激酶。ZM 336372不会阻止生长因子或佛波酯诱导的MKKl或p42 MAPK/ERK2激活。通过抑制MAPK级联反应,蛋白激酶C或磷脂酰肌醇3-激酶不能阻止ZM 336372诱导的c-Raf的激活。ZM 336372处理诱导c-Raf和B-Raf异构体> 100的活化,但它不引发MKKI或p42MAPK/ERKP的任何活化或诱导Ras的GTP加载的任何增加,表明反馈控制环Raf异构体抑制其自身激活,从而抑制总是通过再激活抵消。ZM 336372在胰腺癌细胞系中,也会通过Ser 9上GSK-3β的磷酸化作用抑制糖原合成酶激酶-3β,从而诱导细胞凋亡。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 2 mg/mL (5.13 mM) DMSO : 72 mg/mL (184.9 mM)
Keywords	Raf kinases \| ZM-336372 \| ZM 336372 \| Inhibitor \| inhibit \| Apoptosis \| ZM336372 \| Raf
Inhibitors Related	Lidocaine hydrochloride \| Metronidazole \| 5-Fluorouracil \| Stavudine \| Tributyrin \| Dextran sulfate sodium salt (MW 4500-5500) \| Myricetin \| Sorafenib \| L-Ascorbic acid \| Acetylcysteine \| Sodium 4-phenylbutyrate \| Kaempferol
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| Kinase Inhibitor Library \| Anti-Ovarian Cancer Compound Library \| Anti-Liver Cancer Compound Library \| Glutamine Metabolism Compound Library \| Anti-Obesity Compound Library \| Pain-Related Compound Library \| Tyrosine Kinase Inhibitor Library

Zinc00581684|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子