硫酸长春碱|T1668|TargetMol

Vinblastine sulfate
143-67-9

￥189 1mg 起订

￥423 5mg 起订

￥634 10mg 起订

上海更新日期：2026-01-06

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产品详情:

中文名称：: 硫酸长春碱

英文名称：: Vinblastine sulfate

CAS号：: 143-67-9

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.82%

产品类别：: 抑制剂

货号：: T1668

Product Introduction

Bioactivity

名称	Vinblastine sulfate
描述	Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
细胞实验	Six-well treatment plates are set up that contained 5 × 104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth. (Only for Reference)
激酶实验	Cell based receptor autophosphorylation assays: Autophosphorylation of PDGFR family kinase assays are cell-based enzyme-linked immunosorbent (ELISA) assays using CHO cells expressing wild-type PDGFRβ, chimeric protein PDGFRβ/c-Kit, and PDGFRβ/Flt3 which contain the extracellular and transmembrane domains of PDGFRβ and the cytoplasmic domain of c-Kit, and Flt-3. Cells are grown to confluency in 96-well microtiter plates under standard tissue culture conditions, followed by serum starvation for 16 hours. Briefly, quiescent cells are incubated at 37 °C with increasing concentrations of Tandutinib for 30 minutes followed by the addition of 8 nM PDGF-BB for 10 minutes. Cells are lysed in 100 mM Tris, pH 7.5, 750 mM NaCl, 0.5% Triton X-100, 10 mM sodium pyrophosphate, 50 mM NaF, 10 μg/mL aprotinin, 10 μg/mL leupeptin, 1 mM phenylmethylsulfonyl fluoride, 1 mM sodium vanadate, and the lysate is cleared by centrifugation at 15,000 g for 5 minutes. Clarified lysates are transferred into a second microtiter plate in which the wells are previously coated with 500 ng/well of 1B5B11 anti-PDGFRβ mAb and then incubated for 2 hours at room temperature. After washing three times with binding buffer (0.3% gelatin, 25 mM HEPES, pH 7.5, 100 mM NaCl, 0.01% Tween 20), 250 ng/mL of rabbit polyclonal anti-phosphotyrosine antibody is added and plates are incubated at 37 °C for 60 minutes. Subsequently, each well is washed three times with binding buffer and incubated with 1 μg/mL of horseradish peroxidase-conjugated anti-rabbit antibody at 37 °C for 60 minutes. Wells are washed prior to adding 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), and the rate of substrate formation is monitored at 650 nm.
体外活性	Vinblastine的平均终末半衰期为14.3小时。在新鲜分离的大鼠肝细胞中孵育时，VLB迅速且强烈地渗透进入细胞内，这一过程很可能通过被动扩散机制实现，随后紧密地与细胞结合[3]。Vinblastine通过抑制由肾上腺髓质素诱导的血管生成反应，同时对于有丝分裂滑移也表现出积极效应，导致带有细胞分裂阻滞的单核细胞中出现微核[4]。在产生约50%的细胞死亡和细胞静止或更低浓度下，根据RPD、RICC和RCC的计算，vinblastine显著增加了微核化的单核细胞数量[2]。
体内活性	Vinblastine是一种广泛使用的抗癌化合物，但具有不希望的副作用[6]。VBL与RAP的低剂量组合对人类HCC在体内展现出令人满意的抗血管生成效果[4]。临床相关剂量的Vinblastine在体内抑制CEM细胞中tubulin的棕榈酰化作用（对tubulin去棕榈酰化的影响）[5]。
存储条件	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (5.5 mM), Sonication is recommended. DMSO : 242 mg/mL (266.21 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble)
关键字	Vincaleukoblastine Sulfate \| Vincaleukoblastine \| Vinblastine sulfate \| Vinblastine Sulfate \| Vinblastine \| NSC-49842 \| NSC 49842 \| nAChR \| MicrotubuleAssociated \| Microtubule/Tubulin \| Microtubule Associated \| Inhibitor \| inhibit \| Autophagy
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硫酸长春碱|||Vincaleukoblastine sulfate salt|||NSC49842|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(13年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
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