洛莫司汀|T1601|TargetMol

Lomustine
13010-47-4

￥148 25mg 起订

￥275 50mg 起订

￥488 100mg 起订

上海更新日期：2024-09-23

TargetMol中国（陶术生物）

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联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 洛莫司汀

英文名称：: Lomustine

CAS号：: 13010-47-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.86%

产品类别：: 抑制剂

货号：: T1601

Product Introduction

Bioactivity

Name	Lomustine
Description	Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
Cell Research	Cell lines are routinely grown as monolayers in DMEM supplemented with 10% foetal calf serum, 25 mm HEPES, glutamine and penicillin/streptomycin. Cytotoxicity studies are carried out in HEPES-free medium in a 5% CO2 atmosphere. 750-1000 cells/well are plated in 96 well plates and after overnight incubation are treated for 2 hours with or without 33 μM BG. Temozolomide or CCNU is then added for 1 hour in the same medium, the final DMSO concentration not exceeding 1%. The cells are grown for a further 7 days in fresh medium and assayed for protein content by the NCI sulphorhodamine assay; growth studies show that cells are in log phase growth during the assay period. For the repeat temozolomide dosing schedule cells are given consecutive 24 hours treatments, with fresh medium each day. Assays are carried out at least in duplicate.(Only for Reference)
In vitro	Lomustine对ZR-75-1和U373的生长具有抑制作用，其IC50分别为12 μM和15 μM。Lomustine降低DNA修复蛋白O6-alkylguanine-DNA alkyltransferase的表达水平。[1] Lomustine (420 μM)通过降低抗凋亡蛋白Bcl-2和Bcl-xl的水平，分别在小脑星形细胞瘤细胞、正常人上皮细胞和成纤维细胞中触发通过线粒体途径的凋亡。Lomustine在小脑星形细胞瘤细胞中引起G2/M期的细胞周期延迟，并在HFSN1细胞中以p53独立的方式上调p21蛋白水平。[2]
In vivo	Lomustine可导致延迟性、累积剂量相关的慢性肝毒性，此种肝毒性是不可逆转的且可能致命。[4] 在自发生长肿瘤的猫中，Lomustine可能引起罕见的严重血液学毒性，其III级或IV级中性粒细胞减少症和血小板减少症的发生率分别为4.1%和1.0%。在自发生长肿瘤的猫中，Lomustine倾向于导致进展性中性粒细胞减少症的可能性更大，并且在统计学上显著提高了响应率。[5]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 50 mg/mL (213.95 mM)
Keywords	Autophagy \| Apoptosis \| inhibit \| Lomustine \| NSC79037 \| NSC-79037 \| Inhibitor \| DNA Alkylator/Crosslinker
Inhibitors Related	Guanidine hydrochloride \| Naringin \| Taurine \| Oleic acid \| Gefitinib \| Hydroxychloroquine \| Stavudine \| Tributyrin \| Salicylic acid \| L-Ascorbic acid \| Paeonol \| Sodium 4-phenylbutyrate
Related Compound Libraries	Anti-Cancer Approved Drug Library \| Anti-Cancer Active Compound Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| Anti-Aging Compound Library \| FDA-Approved Drug Library \| Tyrosine Kinase Inhibitor Library \| Drug Repurposing Compound Library \| Anti-Cancer Clinical Compound Library \| Anti-Cancer Drug Library

洛莫司汀|||NSC 79037|||CCNU|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子