双丙戊酸钠|T6474|TargetMol

Divalproex Sodium
76584-70-8

￥273 10mg 起订

￥432 25mg 起订

￥673 50mg 起订

上海更新日期：2024-09-23

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 双丙戊酸钠

英文名称：: Divalproex Sodium

CAS号：: 76584-70-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.84%

产品类别：: 抑制剂

货号：: T6474

Product Introduction

Bioactivity

名称	Divalproex Sodium
描述	Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor， Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels.
体外活性	Divalproex sodium enhances apoptosis, IM-induced cell growth inhibition and cell cycle arrest in K562-G and K562-S cells. It enhances the inhibitory effects of IM on SIRT1 expression in K562-G and K562-S cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1.
体内活性	Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas 50 mg/kg has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC.
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 57 mg/mL (183.6 mM) DMSO : 75 mg/mL (241.62 mM), Sonication is recommended. Ethanol : 58 mg/mL (186.8 mM)
关键字	Mitophagy \| Notch \| Apoptosis \| Histone deacetylases \| Autophagy \| hepatic fat accumulation \| HDAC \| Notch1 \| headaches \| Mitochondrial Autophagy \| small cell lung cancer \| degradation \| epilepsy \| HIV \| Divalproex Sodium \| Endogenous Metabolite \| Valproic acid (sodium)(2:1) \| bipolar disorder \| VPA (sodium)(2:1) \| anticonvulsant \| 2-Propylpentanoic Acid (sodium)(2:1) \| SCLC \| proteasomal \| anticancer \| inhibit \| migraine \| Inhibitor \| Human immunodeficiency virus
相关产品	p-Hydroxybenzaldehyde \| Penicillin G sodium salt \| Valproic acid sodium salt \| 4-Phenylbutyric acid \| Valproic Acid \| Panobinostat \| Theophylline \| Curcumin \| (-)-α-Pinene \| Theophylline monohydrate \| Sodium 4-phenylbutyrate \| Halothane
相关库	抑制剂库 \| 抗癌上市药物库 \| 已知活性化合物库 \| 抗衰老化合物库 \| 抗癌天然产物库 \| 天然产物库 \| FDA 上市药物库 \| 离子通道库 \| 药物功能重定位化合物库 \| 抗癌临床化合物库 \| 高通量筛选天然产物库 \| 抗癌药物库

双丙戊酸钠|||Valproate semisodium|||Epival|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子