去甲斑蝥素|T5656|TargetMol

(±)-Norcantharidin
29745-04-8

￥269 5mg 起订

￥382 10mg 起订

￥659 25mg 起订

上海更新日期：2025-03-12

TargetMol中国（陶术生物）

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联系人：邵小姐

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邮箱：marketing@targetmol.com

产品详情:

中文名称：: 去甲斑蝥素

英文名称：: (±)-Norcantharidin

CAS号：: 29745-04-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: ≥98%

产品类别：: 抑制剂

货号：: T5656

Product Introduction

Bioactivity

名称	(±)-Norcantharidin
描述	(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
细胞实验	Two human colon cancer cell lines, HCT116 and HT29, were used as model systems to investigate the anti-cancer molecular mechanism of NCTD. Cell cycle arrest and early/late apoptosis were analyzed by flow cytometry. The levels of EGFR, phospho-EGFR, c-Met, phospho-c-Met and other related proteins were quantified by western blot analysis[1]
动物实验	The tumor xenograft model of human gallbladder carcinoma in nude mice in vivo was established with subcutaneous GBC-SD cells. The experimental mice were randomly divided into control, 5-FU, NCTD, and NCTD+5-FU groups which were given different treatments. Tumor growth in terms of size, growth curve, and inhibitory rate was evaluated. Cell cycle, apoptosis, and morphological changes of the xenografted tumors were assessed by flow cytometry and light/electron microscopy. The expression of the cell cycle-related proteins cyclin-D1 and p27 as well as the apoptosis-related proteins Bcl-2, Bax, and survivin were determined by the streptavidin-biotin complex (SABC) method and RT-PCR[2].
体内活性	NCTD可能是一种实惠且有效的候选化合物，以替代gefitinib来满足癌症患者的治疗需求[1]。通过诱导凋亡和阻断细胞周期，NCTD在体内抑制裸鼠人类胆囊癌异种移植瘤的生长[2]。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 60 mg/mL (356.82 mM), Sonication is recommended.
关键字	(±) Norcantharidin \| (±)Norcantharidin
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相关库	抑制剂库 \| 经典已知活性库 \| 抗癌上市药物库 \| 抗癌活性化合物库 \| 激酶抑制剂库 \| 抗癌天然产物库 \| 天然产物库 \| 药物功能重定位化合物库 \| 高通量筛选天然产物库 \| 抗感染天然产物库

去甲斑蝥素|||Norcantharidin|||Endothall anhydride|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子