埃博霉素|TQ0202|TargetMol

Epothilone D
189453-10-9

￥6650 5mg 起订

￥2820 1mg 起订

上海更新日期：2026-01-06

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 埃博霉素 D

英文名称：: Epothilone D

CAS号：: 189453-10-9

品牌：: TargetMol

产地：: 美国

保存条件：: store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: TQ0202

Product Introduction

Bioactivity

名称	Epothilone D
描述	Epothilone D is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum that binds to tubulin and inhibits microtubule disassembly, thereby blocking mitosis, cellular proliferation, and cell motility, Epothilone D is extensively utilized in cancer research to study microtubule dynamics, mitotic arrest, and cytoskeleton-targeted anticancer mechanisms.
动物实验	Groups of mice (n=3) receive intraperitoneal (i.p.) injections of 3.7 mg/kg of Epothilone D (epoD) dissolved in 100% DMSO, followed by euthanization using approved at times ranging from 0.25 h to 24 h. In another study, groups of mice (n=3) receive injections of 3 mg/kg of epoD in 100% DMSO followed by euthanization 4, 6 and 10 days later. The Epothilone D (epoD) levels in the brain and blood samples are determined using LC-MS/MS protocols. Groups (n=10-13) of 3-month old PS19 tau Tg mice or 3-month old non-Tg littermates are administered weekly i.p. injections of 1 mg/kg epoD, 3 mg/kg of Epothilone D (epoD) or vehicle (DMSO), for a total of 3 months. Animals are monitored for signs of abnormal behavior or distress and are weighed weekly. After final dosing, the mice undergo motor function and cognitive testing. After euthanization, brains and optic nerve (ON) are recovered for immunohistochemical analyses. A subset of mice from each group also undergo necropsy evaluation with organ weights recorded [2].
体外活性	Epothilone D is a more potent microtubule stabilizer in vitro than epothilone A or B. In vitro, Epothilone D has shown potent cytotoxicity in a panel of human tumor cell lines, with similar potency to paclitaxel. Epothilone D also shows a definite advantage over paclitaxel in drug-resistant cell lines and retained its cytotoxicity against a multidrug-resistant cell line over-expressing P-glycoprotein [1].
体内活性	在模拟阿尔茨海默病特征的 Tauopathy 转基因小鼠模型 (PS19 小鼠) 中，每周腹腔注射 (i.p.) 一次 Epothilone D（1 mg/kg 或 3 mg/kg，持续 3 个月）影响了微管密度和轴突完整性。这些结构变化与处理后小鼠认知指标的改善相关。在这些剂量下，小鼠未表现出体重减轻或中性粒细胞减少，显示出与更高化疗剂量不同的耐受特征 [2]。
存储条件	store at low temperature \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 80 mg/mL (163.36 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (6.74 mM), Sonication is recommended.
关键字	MicrotubuleAssociated \| Microtubule Associated \| microtubule \| KOS-862 \| Epothilone D
相关产品	4-Isopropoxybenzoic acid \| α-Cyclodextrin \| Mebendazole \| Flubendazole \| Oxfendazole \| Methylene Blue \| Methylene Blue trihydrate \| N-Phenylbenzylamine \| Pregnenolone acetate \| Paclitaxel \| 4'-Demethylepipodophyllotoxin \| Albendazole

埃博霉素 D|||Utidelone|||UTD1|||UTD 1|||KOS862|||KOS 862|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(13年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子