Anti-曲妥珠单抗（Trastuzumab）抗体-ACROBiosystems百普赛斯

Anti-Trastuzumab Antibody (AY1b) (recommended for PK/PD)

抗体来源（Source）

Anti-Trastuzumab Antibody (AY1b) is a Mouse monoclonal antibody recombinantly expressed from HEK293 cells.

克隆号（Clone）

AY1b

种属（Species）

Mouse

亚型（Isotype）

Mouse IgG1/kappa

抗体类型（Antibody Type）

Recombinant Monoclonal

种属反应性（Reactivity）

Human

免疫原（Immunogen）

Trastuzumab.

特异性（Specificity）

Recognizes Trastuzumab specifically, no cross reactivity with other humanized antibodies.

应用（Application）

纯度（Purity）

>95% as determined by SDS-PAGE.

纯化（Purification）

Protein A purified/ Protein G purified

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 12 months under sterile conditions after reconstitution.

背景（Background）

曲妥珠单抗是一种用于治疗癌症的单克隆抗体。具体而言，其用于HER2受体阳性的乳腺癌症。曲妥珠单抗通过与HER2受体结合并减缓细胞复制来发挥作用。曲妥珠单抗是一种重组IgG1κ人源化单克隆抗体，在基于细胞的测定中（Kd=5 nM）以高亲和力选择性结合人表皮生长因子受体蛋白的细胞外结构域。