反苯环丙胺盐酸盐|T1025|TargetMol

Tranylcypromine (2-PCPA) hydrochloride
1986-47-6

￥258 50mg 起订

￥413 100mg 起订

￥543 200mg 起订

上海更新日期：2024-12-02

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产品详情:

中文名称：: 反苯环丙胺盐酸盐

英文名称：: Tranylcypromine (2-PCPA) hydrochloride

CAS号：: 1986-47-6

品牌：: TargetMol

产地：: 美国

保存条件：: store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 97.19%

产品类别：: 抑制剂

货号：: T1025

Product Introduction

Bioactivity

名称	Tranylcypromine (2-PCPA) hydrochloride
描述	Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression.
激酶实验	PDE activity is determined with some modifications. The assay mixture contain 50 mM Tris (pH 7.4), 5 mM MgCl2, 0.5 μM cAMP or cGMP, and [3H]cAMP or [3H]cGMP (about 30,000 cpm/assay), the indicated concentration of the inhibitor and an aliquot of the enzyme solution at a final assay volume of 200 μL. Stock solutions of the compounds are diluted 1:100 (v/v) in the Tris buffer mentioned above; appropriate dilutions are prepared in 1% (v/v) DMSO/Tris buffer, which are diluted 1:2 (v/v) in the assays to obtain the desired final concentrations of the inhibitors at a DMSO concentration of 0.5% (v/v). DMSO itself affected none of the PDE activities. After preincubation for 5 min at 37°C, the reaction is started by the addition of substrate (cAMP or cGMP) and the assays are incubated for further 15 min at 37°C. Then 50 μL of 0.2 N HCl is added to stop the reaction and the assays are left on ice for about 10 min. Following incubation with 25 μg of 5′-nucleotidase (Crotalus atrox snake venom) for 10 min at 37°C, the assays are loaded on QAE Sephadex A-25 (1 mL of bed volume in Poly-Prep chromatography columns). The columns are eluted with 2 mL of 30 mM ammonium formate (pH 6.0) and the eluate is counted for radioactivity. Results are corrected for blank values (measured in the presence of denatured protein) that are below 5% of total radioactivity. The amount of cyclic nucleotides hydrolyzed did not exceed 30% of the original substrate concentration[3].
体外活性	与空白对照组相比,Tranylcypromine（5 mg/kg和10 mg/kg）可大而缓的增加雄性大鼠的肌肉活动,但2 mg/kg的Tranylcypromine没有效果. Tranylcypromine（10 mg/kg）使雄性大鼠饲养行为数量显著增加.
体内活性	在小牛主动脉内皮细胞中,Tranylcypromine（500 μg/mL）可强烈抑制缓激肽诱导的花生四烯酸释放。 Tranylcypromine还能抑制HLMs中的CYP2A6（IC50：0.42 μM）和CYP2E1（IC50：3 μM）活性。在HLMs中,Tranylcypromine引起II型和环丙基苯I型的差异谱。HLMs中CYP2A6介导的尼古丁代谢可被R-(+)-Tranylcypromine（Ki：0.05 μM）,(±)-Tranylcypromine（Ki：0.08 μM）以及S-(-)-Tranylcypromine（Ki：2.0 μM）完全抑制。
存储条件	store under nitrogen,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 17 mg/mL (100 mM) DMSO : 65 mg/mL (383.12 mM)
关键字	Tranylcypromine (2-PCPA) Hydrochloride \| Tranylcypromine (2PCPA) hydrochloride \| Tranylcypromine (2 PCPA) hydrochloride
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反苯环丙胺盐酸盐|||Tranylcypromine (2-PCPA) HCl|||SKF-385 HCl|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

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