来氟米特|T1159|TargetMol

Leflunomide
75706-12-6

￥187 10mg 起订

￥314 25mg 起订

￥527 50mg 起订

上海更新日期：2026-01-06

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产品详情:

中文名称：: 来氟米特

英文名称：: Leflunomide

CAS号：: 75706-12-6

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.89%

产品类别：: 抑制剂

货号：: T1159

Product Introduction

Bioactivity

名称	Leflunomide
描述	Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
激酶实验	DHODase activity is measured by the DCIP colorimetric assay. This is a coupled assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent to the reduction of DCIP. Reduction of DCIP is accompanied by a loss of absorbance at 610 nm (ε=21500 M/cm). The assay is performed in a 96-well microtiter plate at ambient temperature (ca. 25°C). Stock solutions of 10 mM leflunomide and A771726 are prepared in dimethyl sulfoxide (DMSO) and these are diluted with reaction buffer (100 mM Tris and 0.1 % Triton X-100, pH 8.0) to prepare working stocks of the inhibitors at varying concentrations. For each reaction, the well contained 10 nM DHODase, 68 μM DCIP, 0.16 mg/mL gelatin, the stated concentration of ubiquinone, 10 μL of an inhibitor working stock to give the stated final concentration, and reaction buffer. After a 5-min equilibration period, the reaction is initiated by addition of DHO to the stated final concentrations. The total volume of reaction mixture for each assay is 150 μL, and the final DMSO concentration is ≤ 0.01% (v/v). The reaction progress is followed by recording the loss of absorbance at 610 nm over a 10-min period (during which the velocity remained linear). Velocities are reported as the change in absorbance at 610 nm per minute, and each reported value is the average of three replicates. In experiments where the DHO or ubiquinone concentration is varied, the other substrate is held constant at 200 μM. To determine the inhibitor potency of leflunomide and A771726, the effects of varying concentrations of the two compounds on the initial velocity of the DHODase reaction is measured over a concentration range of 0.01?1.0 μM. In these experiments the DHO and ubiquinone concentrations are held constant at 200 and 100 μM, respectively.
体外活性	Leflunomide能够防止和逆转啮齿动物、狗、猴等体内同种异体移植物和异种移植物排斥.
体内活性	Leflunomide是一种免疫调节药物,可通过抑制线粒体酶二氢乳清脱氢酶发挥作用。Leflunomide能够抑制抗CD3-和白细胞介素-2（IL-2）刺激的T细胞增殖。Leflunomide也抑制抗CD3单克隆抗体刺激的反应,即人T淋巴细胞中IL-2产生和IL-2受体的表达。Leflunomide也抑制CTLL-4细胞中IL-2刺激的酪氨酸磷酸化。Leflunomide通过干扰由于rUMP产生不足和利用涉及p53的机制而引起的细胞周期进展来阻止活化和自身免疫淋巴细胞的扩增。Leflunomide在体外酪氨酸激酶测定中,能够抑制p59fyn和p56lck活性。
存储条件	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 242.5 mg/mL (897.45 mM), Sonication is recommended. Ethanol : 27 mg/mL (99.92 mM), Sonication is recommended.
关键字	SU-101 \| SU 101 \| RS34821 \| RS 34821 \| Protein-tyrosine kinase 2 \| Leflunomide \| Inhibitor \| inhibit \| HWA-486 \| HWA 486 \| Dihydroorotate Dehydrogenase \| DHODH \| AhR
相关产品	Glycerol \| Aceglutamide \| Levulinic acid \| Emtricitabine \| L-Pyroglutamic acid \| Sucrose \| BES \| Dimethyl sulfoxide \| Gluconate Calcium \| Thymidine \| Sodium diacetate \| D(+)-Raffinose pentahydrate
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来氟米特|||SU101|||RS-34821|||HWA486|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(13年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子