磷酸氯喹|T0194|TargetMol

Chloroquine phosphate
50-63-5

￥298 50mg 起订

￥418 100mg 起订

￥656 200mg 起订

上海更新日期：2026-05-08

TargetMol中国（陶术生物）

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联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 磷酸氯喹

英文名称：: Chloroquine phosphate

CAS号：: 50-63-5

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.95%

产品类别：: 抑制剂

货号：: T006|T0194

Product Introduction

Bioactivity

名称	Chloroquine phosphate
描述	Chloroquine phosphate (Aralen phosphate) is an antimalarial and anti-inflammatory agent widely used for malaria and rheumatoid arthritis. Chloroquine phosphate acts as an inhibitor of autophagy and toll-like receptors, effectively suppressing SARS-CoV-2 (COVID-19) infection (EC50 = 1.13 μM). Chloroquine phosphate can be utilized in research on autophagy, lysosomal function, and tumor diseases.
细胞实验	The cells are cultured in 6-well plates with normal culture medium in the presence of vehicle or 25 or 50 μM chloroquine, until near confluency, after which they are rinsed with sterile phosphate-buffered saline (PBS) and cultured further for the indicated times in serum-free culture medium. At the desired time-points, the culture medium is discarded and the cells are quickly harvested in lysis buffer and clarified by centrifugation. Subsequent to boiling the supernatants in reducing sodium dodecyl sulfate (SDS) sample buffer, equal amounts of protein (100 μg) are loaded per lane and the samples are electrophoresed into 10 or 4-20% gradient polyacrylamide SDS gels, then transferred to a nitrocellulose membrane. To detect TLR9, the blots were incubated overnight at 4°C with anti-TLR9 antibodies, diluted 1:500 in Tris-buffered saline with 0.1% (v/v) Tween-20 (TBST). Equal loading is confirmed with polyclonal rabbit anti-actin. Secondary detection is performed with horseradish peroxidase-linked secondary antibodies. The protein bands are visualized by chemiluminescence using an ECL kit [2].
动物实验	Control and TLR9 siRNA MDA-MB-231 cells (5×105 cells in 100 μL) are inoculated into the mammary fat pads of four-week-old, immune-deficient mice (athymic nude/nu Foxn1). Treatments are started seven days after tumor cell inoculation. The mice are treated daily either with intraperitoneal (i.p.) chloroquine (80 mg/kg) or vehicle (PBS). The animals are monitored daily for clinical signs. Tumor measurements are performed twice a week and tumor volume is calculated according to the formula V=(π/6) (d1×d2)3/2, where d1 and d2 are perpendicular tumor diameters. The tumors are allowed to grow for 22 days, at which point the mice are sacrificed and the tumors are dissected for a final measurement. Throughout the experiments, the animals are maintained under controlled pathogen-free environmental conditions (20-21°C, 30-60% relative humidity and a 12-h lighting cycle). The mice are fed with small-animal food pellets and supplied with sterile water ad libitum [2].
体外活性	方法：选择 Vero E6 细胞 + SARS-CoV Frankfurt 1 株（感染剂量: 100 CCID₅₀），Chloroquine phosphate（1–100 μM）与病毒同时加入，共孵育 3 天，MTS 法检测细胞活力。结果：Chloroquine phosphate 在低微摩尔浓度即有效，且治疗窗口宽。[1] 方法：人/小鼠靶向癌症相关成纤维细胞 CAFs 中加入 ATRA（1 mM）和 Chloroquine phosphate（10 μM），免疫荧光、免疫印迹检测自噬标志物。结果：Chloroquine phosphate 处理抑制 CAF 活化。[2]
体内活性	方法：原位种植 KPC 细胞的小鼠通过腹腔注射游 Chloroquine phosphate (70 mg/kg，每日一次)或静脉注射游离 Chloroquine phosphate (70 mg/kg，每日一次)或静脉注射 CQ-MSC-Lipo (80 μg/只，每 3 天一次)，各组均腹腔注射抗-PD-1(200 μg)。结果：Chloroquine phosphate-MSC-Lipo + 抗-PD-1 效果优于游离 Chloroquine phosphate 联合治疗，显著抑制肿瘤生长。[2]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : Insoluble H2O : 65.625 mg/mL (127.21 mM), Sonication is recommended.
关键字	Toll-like Receptor (TLR) \| TLR9 \| TLR7 \| TLR \| SARS-CoV \| SARSCoV \| SARS coronavirus \| rheumatoid \| Parasite \| malaria \| Inhibitor \| inhibit \| inflammatory \| infection \| immune-modulating \| Human immunodeficiency virus \| HIVProtease \| HIV Protease \| HIV \| COVID-19 \| Chloroquine phosphate \| Chloroquine Diphosphate \| Chloroquine \| Chingamin Phosphate \| Autophagy \| arthritis \| Aralen Phosphate \| Antibiotic
相关产品	2-Amino-2-methyl-1-propanol \| Guanidine hydrochloride \| Aceglutamide \| Fenpyroximate \| Emtricitabine \| Neomycin sulfate \| Terbinafine hydrochloride \| Hemin \| Hydroxychloroquine \| Lamivudine \| Sulfamethoxazole sodium \| Paeonol
相关库	抑制剂库 \| 经典已知活性库 \| 植物来源化合物库 \| 生物碱类天然产物库 \| 临床失败化合物库 \| 苦味化合物库 \| 抗病毒库 \| FDA 上市药物库 \| 免疫/炎症分子化合物库 \| 膜蛋白靶向化合物库 \| 抗寄生虫库 \| 药物功能重定位化合物库

磷酸氯喹;Chloroquine diphosphate;Chingamin phosphate;Aralen phosphate;TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(14年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子