舒更葡糖钠|T5326

Sugammadex sodium
343306-79-6

￥245 5mg 起订

￥393 10mg 起订

￥659 25mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

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联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 舒更葡糖钠

英文名称：: Sugammadex sodium

CAS号：: 343306-79-6

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.44%

产品类别：: 抑制剂

货号：: T5326

Product Introduction

Bioactivity

名称	Sugammadex sodium
描述	Sugammadex sodium (Org25969) , a synthetic derivative of γ-cyclodextrin, is a steroid-based neuromuscular blocker reversing agent.
动物实验	The animals were anesthetized with 80 mg/kg ketamine hydrochloride and 12 mg/kg xylazine administered intraperitoneally. After the rats were anesthetized, the bilateral common carotid arteries were exposed and carefully separated from the carotid sheath and the cervical sympathetic and vagal nerves through a ventral cervical incision. The bilateral common carotid arteries were occluded with nontraumatic aneurysm clips in ischemic rats but were not clamped in sham-operated rats. Complete interruption of the blood flow was confirmed by observing the central artery in the retina with an ophthalmoscope. The body temperature of the rats was maintained at 37.0 ± 0.5°C during this procedure. In this model, 10 minutes of ischemia and 24 hours of reperfusion were induced. After the ischemic period, the rats were treated with sugammadex 16 mg/kg (S 16 group) and sugammadex 100 mg/kg (S 100 group) (intravenous and total volume 1 mL) in the 5th minute of reperfusion. Sugammadex was diluted with normal saline (0.9% NaCl). The same surgical procedure was performed in the I/R group, but the rats were not treated with sugammadex. The neck incision was closed with sutures (3.0 silk), and the animals were allowed to awaken. After 24 hours, the neurological condition of the rats was assessed with a scoring system [2].
体内活性	注射100 ug/kg 的罗库溴铵可以实现平均93.0%的神经肌肉阻滞，而通过注射500 ug/kg 的剂量可以达到深度阻滞。在注射高剂量罗库溴铵后，四连征比率90%的恢复时间分别为：使用生理盐水后28分钟，使用1 mg/kg sugammadex后26分钟，使用2.5 mg/kg sugammadex后缩短至8分钟。在此过程中，没有观察到残留阻滞或再次阻滞的迹象[1]。在短暂全脑缺血/再灌注（I/R）大鼠模型中，16 mg/kg与100 mg/kg sugammadex的治疗表现出神经保护作用，但100 mg/kg的sugammadex对大鼠具有更显著的神经保护效果[2]。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 34 mg/mL (15.61 mM)
关键字	inhibit \| Inhibitor \| anesthesia \| Sugammadex \| Org 25969 \| reversal agent \| neuromuscular block \| Sugammadex sodium \| ischemic \| Org-25969 \| Neuroprotective
相关库	NO PAINS 化合物库 \| 大环化合物库

舒更葡糖钠|||Sugammadex (sodium)|||Org25969|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子