尼索地平|T0163

Nisoldipine
63675-72-9

￥169 25mg 起订

￥233 50mg 起订

￥328 100mg 起订

上海更新日期：2024-09-14

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 尼索地平

英文名称：: Nisoldipine

CAS号：: 63675-72-9

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.51%

产品类别：: 抑制剂

货号：: T0163

Product Introduction

Bioactivity

Name	Nisoldipine
Description	Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
Cell Research	The myocytes are bathed in normal Tyrode's solution, held at -80 mV, and depolarised after 200-ms prepulses (-40mV) to more positive potentials for 500 ms at 0.1 Hz, tail currents are recorded on repolarisations to -40mV. The myocytes are exposed to 10-100 mM Nisoldipine for 8-10 minutes. Then the whole-cell membrane currents are recorded using an EPC-7 amplifier.(Only for Reference)
Kinase Assay	Binding experiments of electrophysiology: CHO cells expressing the subunit of the voltage-dependent L-type Ca2+ channel are cultrured in medium without serum in the presence of different concentrations of Nisoldipine. Then Ca2+ channel current elicited from a holding potential of -100 mV or -50 mV is recorded at room temperature with the whole-cell configuration of the patch-clamp method using the List EPC-7 patch-clamp amplifer and pClamp software. The concentration of competitor inhibiting 50% of the specific binding represents IC50.
In vitro	对于Timothy综合征病人,Nisoldipine（IC50=267 nM）通过抑制钙离子从L型钙通道流入,降低动脉平滑肌收缩性及随后的血管收缩 , 导致血管舒张,且降低血压.
In vivo	在豚鼠心室肌细胞中,Nisoldipine延迟整流K+通道,快速激活延迟整流K+通道抑制IKr(IC50=23 μM), 及缓慢激活延迟整流K+通道抑制IKs(IC50=40 μM)。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 56 mg/mL (144.2 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 50 mg/mL (128.73 mM)
Keywords	Reactive Oxygen Species \| Nisoldipine \| Inhibitor \| inhibit \| Calcium Channel \| Ca2+ channels \| Ca channels
Inhibitors Related	Lycopene \| Coenzyme Q10 \| Sodium Thiocyanate \| Glucosamine \| 2-Nitrobenzoic acid \| 3-Amino-1,2,4-triazole \| Ethyl cinnamate \| Ammonium sulfate \| Imeglimin hydrochloride \| Acetylcysteine \| L-Ascorbic acid \| Naringenin
Related Compound Libraries	Neuroprotective Compound Library \| Anti-Cancer Approved Drug Library \| Bioactive Compounds Library Max \| Anti-Aging Compound Library \| FDA-Approved Drug Library \| Ion Channel Targeted Library \| Immunology/Inflammation Compound Library \| Membrane Protein-targeted Compound Library \| Pain-Related Compound Library \| Drug Repurposing Compound Library \| Anti-Cancer Clinical Compound Library \| Anti-Cancer Drug Library

尼索地平|||BAY-k 5552|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子