亚甲蓝|T6888

Methylene Blue
61-73-4

￥713 500mg 起订

￥239 50mg 起订

￥418 100mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

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联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 亚甲蓝

英文名称：: Methylene Blue

CAS号：: 61-73-4

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 96.82%

产品类别：: 抑制剂

货号：: T6888

Product Introduction

Bioactivity

名称	Methylene Blue
描述	Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
细胞实验	Immature neuroblasts, isolated from the newborn rat subventricular zone, differentiate into γ-aminobutyric acid–mediated neurons are exposed at the sixth day in vitro to MB (10 μM) for 2h. Assess the survival and dendritic arbor architecture of these cells 48h after this treatment paradigm.
激酶实验	Isolated Integrin Binding Assays.:Purified integrin (1 μg/mL; 4℃) is used to coat 96-well microtitre plates, which are then blocked with bovine serum albumin (BSA) (3% in 1 mM CaCl2, 1 mM MgCl2,10 pM MnCl2, 100 mM NaC1,50 mM Tris-hydroxymethyl-aminomethane; pH 7.4), and incubated (3 h at 30 ℃) with biotinylated ligands (1 pg/mL in binding buffer: 0.1% BSA, 1 mM CaCl2,1 mM MgCl2, 10 μM MnCl2, 100 mM NaCl, 50 mM Tris-hydroxymethyl-aminomethane; pH 7.4) in the presence or absence of serially diluted peptides. After washing (3×5 min with binding buffer), the bound biotinylated ligand is detected with alkaline-phosphatase conjugated goat anti-biotin antibodies (1 μg/mL; 1 h, 37℃), using p-nitrophenyl phosphate as chromogen. Cyclo (-RGDfK) binding in the absence of competitor is defined as 100% signal; binding to blocked wells in the absence of integrin is defined as 0%. Concentrations of Cyclo (-RGDfK) required for 50% inhibition of signal (IC50 values) are estimated graphically.
动物实验	MB (5 or 50 mg/kg) diluted in normal saline were injected intraarterially into Sprague- Dawley male rats over the 30s.
体外活性	MB通过产生超氧阴离子直接灭活一氧化氮，并可能抑制一氧化氮合酶自身的活性。除了干扰一氧化氮-环磷酸鸟苷通路外，MB还直接激活钙依赖性钾通道并增强去甲肾上腺素从细胞内储存的释放。
体内活性	Methylene Blue通过抑制鸟苷酸环化酶来降低C-GMP和血管平滑肌的放松。药代动力学研究表明，通过血管给药的MB会快速且大量积聚于中枢神经系统(CNS)。静脉注射MB时，它会选择性地聚集在甲状旁腺，因此在手术过程中易于识别这些结构。
存储条件	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 3.2 mg/mL (10 mM) DMSO : 1 mg/mL, Sonication is recommended.
关键字	antimalarial \| anxiolytic \| inhibit \| Parasite \| Methylthioninium \| methemoglobinemias \| Monoamine Oxidase \| cGMP \| CI 52015 \| Nitric oxide synthases \| NOS \| Tetramethylthionine Chloride \| Inhibitor \| antinociception \| CI52015 \| antidepressant \| Methylene Blue \| dye \| methylthioninium Chloride \| MAO \| vasopressor \| Basic Blue-9 \| Guanylate Cyclase \| Basic Blue9 \| NO Synthase
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亚甲蓝|||亚甲兰|||Tetramethylthionine chloride|||methylthioninium chloride|||CI-52015|||Basic Blue 9|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子