化合物 OG-L002|T6073

OG-L002
1357302-64-7

￥247 1mg 起订

￥376 2mg 起订

￥679 5mg 起订

上海更新日期：2024-09-14

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 化合物 OG-L002

英文名称：: OG-L002

CAS号：: 1357302-64-7

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 97.05%

产品类别：: 抑制剂

货号：: T6073

Product Introduction

Bioactivity

Name	OG-L002
Description	OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.
Cell Research	HeLa or HFF cells are treated with the indicated concentrations of saponin (positive control) or compound OG-L002 for 12 hours. Cytotoxicity is determined using conditions recommended by the manufacturer and expressed as ratios to the cytotoxicity of the DMSO control.(Only for Reference)
Kinase Assay	LSD1 demethylation assay: Human recombinant LSD1 protein is incubated with dimethylated H3K4 peptide as the substrate in the presence of various concentrations of lead compound inhibitors (0 to 75 μM ) or control tranylcypromine. The demethylase activity is measured by the release of Water2 produced during the catalytic process, using the Amplex red peroxide/peroxidase-coupled assay kit. Each reaction is done in triplicate. The maximum LSD1 demethylase activity is obtained in the absence of inhibitor and corrected for background fluorescence. The Ki (IC50) of OG-L002 is calculated as half-maximal activity.
In vitro	OG-L002 在HeLa和HFF细胞中强效抑制HSV IE基因表达，其IC50分别约为10μM和3μM。50μM的OG-L002处理导致子代病毒产量减少，且在HeLa或HFF细胞中未显示出显著毒性。此外，50μM的OG-L002增加了病毒IE基因启动子上抑制性染色质的水平，并抑制了hCMV IE基因和腺病毒E1A基因的表达。[1]
In vivo	OG-L002（6至40 mg/kg）在小鼠模型中以剂量依赖的方式抑制HSV初次感染。此外，OG-L002还能在小鼠神经节解剖模型中抑制HSV从潜伏状态的复发。[1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 16 mg/mL (71 mM) DMSO : 55 mg/mL (244.13 mM), Sonication is recommended.
Keywords	Inhibitor \| MAO-B \| LSD1 \| oxidases \| HSV \| Histone Demethylase \| OG-L002 \| MAO \| inhibit \| monoamine \| Herpes simplex virus \| OGL002 \| MAO-A \| OG L002 \| Monoamine Oxidase \| OG-L-002 \| OG-L 002
Inhibitors Related	Oxyresveratrol \| Acyclovir \| Floxuridine \| Ganciclovir \| 2-Deoxy-D-glucose \| Methylene Blue trihydrate \| Isatin \| Idoxuridine \| S-Methylisothiourea sulfate \| Oxytetracycline Hydrochloride \| Paeonol \| Azure B
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| Mitochondria-Targeted Compound Library \| Chromatin Modification Compound Library \| Anti-Aging Compound Library \| NO PAINS Compound Library \| Epigenetics Compound Library \| Anti-Viral Compound Library \| Reprogramming Compound Library

OG-L002|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子

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