埃博霉素 A|T6490

Epothilone A
152044-53-6

￥223 1mg 起订

￥448 5mg 起订

￥708 10mg 起订

上海更新日期：2024-09-14

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 埃博霉素 A

英文名称：: Epothilone A

CAS号：: 152044-53-6

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.48%

产品类别：: 抑制剂

货号：: T6490

Product Introduction

Bioactivity

Name	Epothilone A
Description	Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM.
Cell Research	Cell lines: KB3-1,KBV-1,Hela,and Hs578T cells. Concentrations: 0–2 μM. Method: cells are plated either in 48-well plates (for trypan blue and cell counting) or onto coverslips.After 24 hours,cells are treated with Epothilone A and are scored at regular intervals.For the cytotoxicity analysis,cells are counted and scored as trypan blue positive or negative.
Kinase Assay	Tubulin polymerization assay: Samples for electron microscopy are placed on carbon-over-Parlodion-coated grids (300 mesh) and negatively stained with 2% uranyl acetate. Microtubule assembly in the presence or absence of Epothilone A is monitored spectrophotometrically by using a spectrophotometer equipped with a thermostatically regulated liquid circulator. The temperature is held at 35 °C and changes in turbidity (representative of polymer mass) are monitored at 350 nm. Effective concentration (EC0.01), defined as the interpolated concentration capable of inducing an initial slope of 0.01 OD/min rate, is calculated using the formula EC0.01 = concentration/slope.
In vivo	Epothilone A诱导微管蛋白聚合, 导致细胞周期在G2-M期停滞, 具有细胞毒性,也诱导细胞凋亡。Epothilone A有效抑制HCT116细胞增殖,IC50为4.4 nM。Epothilone A 对KB3-1, KBV-1, Hela和 Hs578T细胞具有细胞毒性,IC50为13 nM到160 nM。Epothilone A与紫杉醇竞争性与微管结合,IC50为2.3 μM。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 92 mg/mL (186.4 mM) DMSO : 92 mg/mL (186.4 mM)
Keywords	Inhibitor \| inhibit \| Apoptosis \| Epothilone A \| Microtubule/Tubulin
Inhibitors Related	Meclizine dihydrochloride \| Oleic acid \| Metronidazole \| 5-Fluorouracil \| Dextran sulfate sodium salt (MW 4500-5500) \| Stavudine \| Tributyrin \| Myricetin \| Sorafenib \| L-Ascorbic acid \| Salicylic acid \| Sodium 4-phenylbutyrate
Related Compound Libraries	Microbial Natural Product Library \| Inhibitor Library \| Anti-Cancer Active Compound Library \| Anti-Tumor Natural Product Library \| Anti-Aging Compound Library \| Natural Product Library \| Microtubule-Targeted Compound Library \| Natural Product Library for HTS

埃博霉素 A|||epothile|||Epo A|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子