卡泊三醇一水合物|TQ0244

Calcipotriol monohydrate
147657-22-5

￥233 1mg 起订

￥523 5mg 起订

￥778 10mg 起订

上海更新日期：2024-09-14

TargetMol中国（陶术生物）

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联系人：邵小姐

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产品详情:

中文名称：: 卡泊三醇一水合物

英文名称：: Calcipotriol monohydrate

CAS号：: 147657-22-5

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.57%

产品类别：: 抑制剂

货号：: TQ0244

Product Introduction

Bioactivity

Name	Calcipotriol monohydrate
Description	Calcipotriol monohydrate is an analog of Vitamin D3 with a high affinity for the vitamin D receptor. Calcipotriol monohydrate can be used for studies about psoriasis.
Cell Research	Normal human epidermal keratinocytes are grown in serum-free keratinocyte growth medium Epilife and used at the third passage in all experiments. The growth supplement is omitted 48 h before experiments. As a control, IL-17A and IL-22 are either added or not added to the cells. Cultured NHEK cells are stimulated with IL-17A (200 ng/mL) and/or IL-22 (200 ng/mL) followed by co-incubation in the presence or absence of Calcipotriol at 0.2-40 nM to test its modulatory effect. Cells are harvested 3 days later and subjected to real-time qPCR. Culture supernatants are also collected and frozen at -80°C until used for ELISA [1].
Animal Research	The 160 female SKH-1 hairless mice (6-7 weeks of age) are used. After UV treatment, mice without tumors are randomly divided into five groups, four chemoprevention groups (Diclofenac plus DFMO; Diclofenac plus Calcipotriol; DFMO plus calcitriol; and Diclofenac plus DFMO plus Calcipotriol) and one placebo group (skin lotion). The mice are treated with test mixtures once a day, five days a week, for a total of 17 weeks. The test mixtures are applied topically on the dorsal surface of the mice. Ten microliters are applied by a pipette after which the mixture is rubbed onto the skin. This corresponded to the following doses of each active substance in the treatments: 100 μg/week for Diclofenac (30 mg/g undiluted), 0.166 μg/week for Calcitriol (50 μg/g undiluted), and 463.3 μg/week for DFMO (139 mg/g undiluted) [3].
In vitro	Calcipotriol monohydrate（100, 10, 和 1 ng/mL）显著提升了NK细胞表面NKp30的表达量，在4小时的孵育后[1]。当NHEK细胞未被IL-17A或IL-22刺激时，Calcipotriol monohydrate轻微增强（0.2 nM）IL-8 mRNA表达，或无影响（2-20 nM）。加入IL-17A和IL-22后，IL-8的mRNA表达显著提升，证实了我们之前的研究。这种IL-8 mRNA表达的增强，通过Calcipotriol monohydrate（2, 20 和 40 nM）以剂量依赖方式被抑制[2]。
In vivo	在经过Diclofenac加Calcipotriol monohydrate（p=0.018）和Diclofenac加DFMO加Calcipotriol monohydrate（p=0.002）处理的组别中，与安慰剂（线性回归模型）[3]相比，体重增加显著较小。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 95 mg/mL (220.61 mM), Sonication is recommended. DMSO : 95 mg/mL (220.61 mM), Sonication is recommended.
Keywords	VD/VDR \| Vitamin D receptor \| Calcipotriol \| Vitamin D \| Calcipotriol monohydrate \| Calcipotriol Monohydrate \| inhibit \| Inhibitor
Inhibitors Related	Retinyl acetate \| Ercalcitriol \| Ercalcidiol \| 24, 25-Dihydroxy VD2 \| (24S)-24,25-Dihydroxyvitamin D3 \| DL-Panthenol \| Maxacalcitol \| Biotin \| 5,6-trans-Vitamin D3 \| Impurity C of Calcitriol \| Calcipotriol \| Acenocoumarol

卡泊三醇一水合物|||钙泊三醇一水合物|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子