左亚叶酸钙|T6431

Levoleucovorin Calcium
80433-71-2

￥233 10mg 起订

￥372 25mg 起订

￥538 50mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 左亚叶酸钙

英文名称：: Levoleucovorin Calcium

CAS号：: 80433-71-2

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice.

纯度规格：: ≥98%

产品类别：: 抑制剂

货号：: T6431

Product Introduction

Bioactivity

Name	Levoleucovorin Calcium
Description	Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.
Kinase Assay	Chk1 Assay: For the Chk1 assay, the kinase domain is expressed in Sf9 insect cells, and a biotinylated cdc25c peptide containing the consensus Chk1/Chk2 phosphorylation site ()(biotin-[AHX]SGSGSGLYRSPSMP-ENLNRPR[CONH2]) is used as the substrate. A dilution series of CHIR-124 is mixed with a kinase reaction buffer containing a final concentration of 30 mM Tris-HCl (pH 7.5), 10 mM MgCl2, 2 mM DTT, 4 mM EDTA, 25 mMβ-glycerophosphate, 5 mM MnCl2, 0.01% bovine serum albumin, 1.35 nM CHK1 kinase domain, 0.5 μM peptide substrate, and 1 AM unlabeled ATP, plus 5 nM 33Pγ-labeled ATP (specific activity = 2,000 Ci/mmol). Reactions and detection of the phosphate transfer are carried out by a radioactive method. Reactions are incubated at room temperature for 1 to 4 hours and the phosphorylated peptide captured on streptavidin-coated microtiter plates containing stop reaction buffer (25 mM EDTA [ethylenediaminetetraacetic acid], 50 mMHEPES, pH 7.5). Phosphorylated peptide is measured with the DELFIA TRF system using a Europium-labeled anti-phosphotyrosine antibody PT66. The concentration of CHIR-124 for IC50 is calculated using nonlinear regression with XL-Fit data analysis software.
Storage	keep away from direct sunlight,store at low temperature,store under nitrogen \| Powder: -20°C for 3 years \| Shipping with blue ice.
Solubility Information	DMSO : Insoluble, The compound is unstable in solution, please use soon. H2O : 10 mM
Keywords	CL-307782 \| Antifolate \| inhibit \| anticancer \| Levoleucovorin Calcium \| CL 307782 \| 5-Fluorouracil \| antineoplastic \| Levoleucovorin \| Inhibitor
Inhibitors Related	Trimethoprim \| Pemetrexed \| Levomefolate calcium \| Diaveridine \| Pyrimethamine \| Methotrexate \| Folinic acid \| Methotrexate metabolite \| Folinic acid calcium \| Pemetrexed disodium

左亚叶酸钙|||CL307782|||Calcium Levofolinate|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子