西维来司钠四水合物|T20762

Sivelestat sodium tetrahydrate
201677-61-4

￥163 1mg 起订

￥359 5mg 起订

￥578 10mg 起订

上海更新日期：2024-09-14

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 西维来司钠四水合物

英文名称：: Sivelestat sodium tetrahydrate

CAS号：: 201677-61-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.64%

产品类别：: 抑制剂

货号：: T20762

Product Introduction

Bioactivity

Name	Sivelestat sodium tetrahydrate
Description	Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
In vitro	Sivelestat (ONO-5046) does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM[1]. Sivelestat (ONO-5046) exhibits IC50 values of 44 nM, 36 nM, 19 nM, 37 nM and 49 nM for human, rabbit, rat, hamster and mouse neutrophil elastase, respectively[1].
In vivo	Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamster (ID50 = 82 pg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which are induced by human neutrophil elastase[1]. Sivelestat (10 mg/kg, infusion via the tail vein) ameliorates lung injury after hemorrhagic shock in rats[2]. Sivelestat (15, 60 mg/kg, ip) prevents ischemia–reperfusion injury in the rat bladder[3].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 225 mg/mL (425.7 mM), Sonication is recommended.
Keywords	ONO-5046 sodium Tetrahydrate \| Elaspol sodium \| ONO5046 sodium \| Sivelestat sodium \| ONO5046 sodium Tetrahydrate \| ONO-5046 sodium \| Elaspol sodium Tetrahydrate \| Sivelestat sodium Tetrahydrate
Inhibitors Related	2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- \| PMSF \| Leupeptin Hemisulfate \| Ceritinib \| Pirodomast \| Benzamidine hydrochloride \| Aprotinin \| Nafamostat mesylate \| AEBSF hydrochloride \| 4-Aminobenzamidine dihydrochloride
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| FDA-Approved & Pharmacopeia Drug Library \| Approved Drug Library \| Anti-Viral Compound Library \| Drug Repurposing Compound Library

西维来司钠四水合物|||Sivelestat Sodium Hydrate|||Sivelestat Sodium|||ONO-5046 sodium tetrahydrate|||ONO5046 sodium tetrahydrate|||ONO-5046|||ONO5046|||ONO 5046|||Elaspol sodium tetrahydrate|||Elaspol|TargetMol

公司简介

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子