化合物Noopept|T7108

Omberacetam
157115-85-0

￥198 2mg 起订

￥328 5mg 起订

￥528 10mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 化合物Noopept

英文名称：: Omberacetam

CAS号：: 157115-85-0

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: ≥95%

产品类别：: 抑制剂

货号：: T7108

Product Introduction

Bioactivity

名称	Omberacetam
描述	Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.
细胞实验	PC12 cells were cultured routinely at 37°C in DMEM medium, supplemented with 10% fetal bovine serum (FBS), 5% horse serum, 2 mM L-glutamine, 50 μg/ml gentamicin. To induce PC12 differentiation, NGF (50 ng/ml) was added to the DMEM containing 1% FBS, followed by a 5-day incubation. Differentiated PC12 (dPC12) cells were pretreated with noopept at concentration of 10 μM for 72 h, then cells were rinsed with the medium and exposed to amyloid-β-peptide (Аβ25–35;5 μM) for 24 h. Untreated cells were used as control[1].
动物实验	Experiments were carried out on adult outbred albino male rats (n=376; 250-300 g) kept under vivarium conditions with 12-h light period with free access to water and standard food. The operant training was performed in a modified setup for active avoidance conditioning under conditions of uncertain environment.The animals were intraperitoneally injected (1 ml/kg) with noopept (0.1, 0.5, and 1.0 mg/kg) and piracetam (100, 300, and 500 mg/kg; reference drug), afobazol (1, 5, and 10 mg/kg), and buspiron (0.5, 1.0, and 5.0 mg/kg; reference drug) and diazepam (0.05, 0.1, and 0.5 mg/kg; reference drug). Control rats were injected with the same volume of saline. Stability of active avoidance behavior was tested after 48 h and 7 days. The animals with learned helplessness neurosis were injected with noopept and afobazol for 21 days, after which stability of the active avoidance behavior was repeatedly tested[2].
体外活性	Omberacetam（以10 μM浓度加入培养基，于Аβ 25-35前72小时）对Аβ 25-35（5 μM，24小时）诱导的PC12细胞损伤的神经保护作用进行了研究。考察了化合物对由Аβ 25-35引起的细胞活性、钙稳态、ROS水平、线粒体功能、tau蛋白磷酸化以及神经突起生长损伤的保护能力。PC12细胞暴露于Аβ 25-35后，观察到ROS水平、细胞内钙和Ser396处tau蛋白磷酸化水平的增加；这些改变伴随着细胞活性下降和凋亡增加。Omberacetam处理改善了PC12细胞的存活率，降低了早期和晚期凋亡细胞的数量，减少了细胞内活性氧和钙的水平，提高了线粒体膜电位。此外，Omberacetam预处理显著减轻了Аβ25-35引起的tau蛋白在Ser396处的过度磷酸化，并改善了神经突起生长的变化。
体内活性	Noopept在长期(21天)治疗后通过提高受训动物的百分比[2]，消除了学习性无助的表现。
存储条件	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 100 mg/mL (314.10 mM)
关键字	Inhibitor \| iGluR \| Ionotropic glutamate receptors \| GVS 111 \| Omberacetam \| inhibit \| SGS 111 \| GVS111 \| SGS111
相关产品	Piracetam \| Quinolinic acid \| L-Glutamic acid \| glycine \| Linalool \| L-Glutamic acid monosodium salt \| Memantine hydrochloride \| D-Cycloserine \| Decanoic Acid \| (-)-Aspartic acid \| Ifenprodil Tartrate \| Mephenesin
相关库	神经保护化合物库 \| 经典已知活性库 \| 抗癌化合物库 \| 已知活性化合物库 \| ReFRAME 相关化合物库 \| 神经递质受体化合物库 \| NO PAINS 化合物库 \| 离子通道库 \| 膜蛋白靶向化合物库 \| 人代谢物化合物库

SGS-111|||Noopept|||GVS-111|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子