盐酸左布比卡因|T6566

Levobupivacaine hydrochloride
27262-48-2

￥167 10mg 起订

￥271 25mg 起订

￥347 50mg 起订

上海更新日期：2024-09-14

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 盐酸左布比卡因

英文名称：: Levobupivacaine hydrochloride

CAS号：: 27262-48-2

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.93%

产品类别：: 抑制剂

货号：: T6566

Product Introduction

Bioactivity

Name	Levobupivacaine hydrochloride
Description	Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local anesthetic.
Kinase Assay	Hsp90 Binding Assay: Human Hsp90α solution (0.5 μg/mL) is fixed on 96-well plates, followed by blocking with TBS containing 1% bovine serum albumin. KW-2478 solutions is added to the wells, and bRD is added to a concentration of 0.1 μmol/L. After removal of solution, poly-HRP streptavidin solution dilutes with poly-HRP dilution buffer is added to the wells. After removal of solution, equal volumes of TMB peroxidase substrate and peroxidase solution B are added to the wells. To stop the HRP reaction, 2 mol/L H2SO4 are added, followed by measurement of absorbance at 450 nm using a microplate spectrophotometer.
In vitro	Levobupivacaine is an amide-type local anaesthetic. Levobupivacaine acts via blockade of voltage-sensitive ion channels in neuronal membranes, preventing transmission of nerve impulses. Localised and reversible anaesthesia is produced by interference with the opening of the sodium channel, which inhibits conduction of the action potential in nerves involved in sensory and motor activity and sympathetic activity. [1] Levobupivacaine displaces 3H-BTX from sodium channels of rat brain synaptosomes with IC50 of 2.9 μM and Hill coefficients of 1.2. When cell membrane is held at -80 mV, -70 mV, -60 mV or -100 mV, Levobupivacaine shows tonic inhibition of sodium channel in GH3 cells with IC50s of 132.1, 37.6, 21.6 and 264 μM, respectively. [2] Levobupivacaine depresses action potential of isolated axon in vitro. Levobupivacaine (1 mM) depresses action potential amplitude and maximal rate of rise of action potential (dV/dtmax) in the crayfish giant axons with value of 88 and 81 respectively, after perfusion for 15 min. [3] Levobupivacaine also displays activity on cardiac ion channels. In isolated ventricular myocytes, the apparent affinity for inactivated state of the sodium channel is 4.8 μM for Levobupivacaine, with a calculated KD of 39 μM. On inhibition of cardiac delayed rectifier potassium channels (hKv1.5), the steady-state block for Levobupivacaine (20 μM) is 31%, with a calculated KD of 27.3 μM. Levobupivacaine may also inhibit cardiac calcium channels. 10 μM Levobupivacaine produces a 50% decrease in contractile force of guinea-pig papillary muscles. [4]
In vivo	Levobupivacaine has similar nerve blocking potency with bupivacaine. Levobupivacaine at a dose of 0.125%, inhibits motor and nocifensive pinch responses with maximum %MPE of 99 and 68 respectively, and inhibits the duration of deficits of motor and nocifensive pinch responses (60 and 30 , respectively) after sciatic nerve block. [4]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 53 mg/mL (163.1 mM) H2O : 59 mg/mL (181.6 mM) DMSO : 50 mg/mL (153.9 mM)
Keywords	CNS toxicity \| gastric cancer \| Na channels \| Erastin \| Inhibitor \| analgesic \| anaesthetic \| Levobupivacaine Hydrochloride \| Na+ channels \| Levobupivacaine hydrochloride \| Sodium Channel \| cardiac toxicity \| Bupivacaine HCl \| CYP450 \| Ferroptosis \| inhibit \| Levobupivacaine \| NMDA \| Bupivacaine \| Bupivacaine Monohydrochloride
Inhibitors Related	Lidocaine hydrochloride \| L-Aspartic aicd sodium \| Phenytoin sodium
Related Compound Libraries	Neuroprotective Compound Library \| Inhibitor Library \| Bioactive Compound Library \| Ion Channel Targeted Library \| Membrane Protein-targeted Compound Library \| Pain-Related Compound Library \| Drug Repurposing Compound Library \| Anti-Cancer Clinical Compound Library \| Anti-Cancer Drug Library

盐酸左布比卡因|||Levobupivacaine HCl|||(S)-(-)-Bupivacaine monohydrochloride|||(S)-(-)-Bupivacaine HCl|TargetMol

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