奈非西坦|T0169

Nefiracetam
77191-36-7

￥123 25mg 起订

￥163 50mg 起订

￥263 100mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 奈非西坦

英文名称：: Nefiracetam

CAS号：: 77191-36-7

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 100%

产品类别：: 抑制剂

货号：: T0169

Product Introduction

Bioactivity

名称	Nefiracetam
描述	Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions.
细胞实验	The injected oocytes are transferred to the recording chamber 24 to 48 hours after incubation and continuously superfused at room temperature (20 to 22 °C) in a standard frog Ringer's solution (115 mM NaCl, 2 mM KCl, 1.8 mM CaCl2, and 5 mM HEPES, pH 7.0). Ca2+ -free extracellular solution consisted of 115 mM NaCl, 2 mM KCl, 5 mM MgCl2, 5 mM HEPES, and 1 mM EGTA, pH 7.0. To remove the effect of the muscarinic ACh receptor, 1 μM atropine is added to the extracellular solution. ACh-activated currents are recorded using two-electrode, voltage-clamp techniques. The currents are analyzed on a microcomputer using pClamp software. ACh is bath-applied to oocytes. Nefiracetam is dissolved in distilled water at 1 mM for stock solution and diluted into concentrations required with the extracellular solution. (Only for Reference)
激酶实验	Assay of glutamate released: Hippocampal slices (400 μM) are prepared from the guinea pig brain using standard techniques. A slice is fixed on a pair of silver wire electrodes (10 Hz, 5 V, 0.1 ms in duration) at 1-minutes intervals for 10 minutes and submerged in 1 mL standard artificial cerebrospinal fluid (ACSF) (in mM: 125 mM NaCl, 5 mM KCl, 1.24 mM KH2PO4, 1.3 mM MgSO4, 2 mM CaCl2, 26 mM NaHCO3, and 10 mM glucose) oxygenated with 95% O2 and 5% CO2 at 36 °C in the presence and absence of tetrodotoxin (TTX) (0.5 μM). In a different set of experiments, electrical stimulation is applied to slices treated with Nefiracetam (1 μM) in the presence and absence of α-bungarotoxin (50 nM) or mecamylamine (3 μM). A 100 μL aliquot of the medium filtered with millipore filters (0.45 μM) is injected onto the cation-exchanger column of the autoanalyser to separate amino acids and the amount of glutamate released is calculated using known amino acid standard concentrations.
体外活性	在DDY小鼠体内,Nefiracetam（>10 mg/kg）也会有效抑制Ro 5-4864诱导的抽搐.口服Nefiracetam可抑制EL小鼠体内Ro 5-4864诱导的惊厥.在每次训练项目前,Nefiracetam给药（1 time/day)有利于回避反应的获得过程.
体内活性	Nefiracetam(0.01–0.1 μM)诱导Ach激发电流的短期抑制,Nefiracetam(1–10 μM)对电流具有长期增强作用。1 μM的Nefiracetam增加2倍钙通道电流的长效组分,而不改变瞬变组分。Nefiracetam处理10分钟后,Ach诱发的电流减少到对照组的30% (0.01 μM)和38%(0.1 μM)。Nefiracetam可与PKC通路发生相互作用提高烟碱Ach受体的活性,进而增加从突出前末梢谷氨酸的释放量,使海马神经传递的持久易化。认知能力增强剂发挥作用的细胞机理可能是通过Nefiracetam与PKA和PKC通路的相互作用造成的。在大鼠海马神经元的原代培养中,Nefiracetam增加烟碱敏感的兴奋性突触后电流比率。在大鼠海马切片的CA1区和齿状回中,Nefiracetam诱导突触传导的持久易化, α-银环蛇毒素和美加明可抑制该易化作用。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 70 mg/mL (284.21 mM), Sonication is recommended. Ethanol : 24.6 mg/mL (100 mM)
关键字	Nefiracetam \| DZL 221 \| γ-Aminobutyric acid Receptor \| GABA Receptor \| DM 9384 \| inhibit \| Inhibitor \| DZL221 \| DM-9384 \| Gamma-aminobutyric acid Receptor
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奈非西坦|||DZL-221|||DM9384|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子