重组人CD2 / SRBC蛋白-ACROBiosystems百普赛斯

Human CD2 / SRBC Protein, His Tag (MALS verified)

分子别名（Synonym）

CD2,SRBC,LFA-2,T11

表达区间及表达系统（Source）

Human CD2, His Tag (CD2-H5226) is expressed from human 293 cells (HEK293). It contains AA Lys 25 - Asp 209 (Accession # AAH33583).

Predicted N-terminus: Lys 25

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 22.3 kDa. The protein migrates as 33-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

T细胞表面抗原CD2也称为红细胞受体、LFA-2、LFA-3受体、Rosette受体、T细胞表面抗体T11/Leu-5和SRBC，是一种存在于T细胞和自然杀伤（NK）细胞表面的单程I型膜蛋白。CD2是免疫球蛋白超家族的成员。CD2/SRBC包含1个Ig-like C2型（免疫球蛋白样）结构域和1个Ig-like V型（免疫蛋白样）功能域。CD2/SRBC与其他粘附分子相互作用，如人类淋巴细胞功能相关抗原-3（LFA-3/CD58）或啮齿动物的CD48，这些分子在其他细胞表面表达。除了其粘附特性外，CD2还充当T细胞和NK细胞的共刺激分子。CD2是T细胞和NK细胞的特异性标记，因此可用于免疫组织化学以鉴定组织切片中此类细胞的存在。