重组人CD98蛋白-ACROBiosystems百普赛斯

Human CD98 Protein, His Tag (MALS verified)

分子别名（Synonym）

SLC3A2,CD98,4F2,4F2HC,4T2HC,CD98HC,MDU1,NACAE

表达区间及表达系统（Source）

Human CD98, His Tag (CD8-H5247) is expressed from human 293 cells (HEK293). It contains AA Arg 206 - Ala 630  (Accession # AAH01061).

Predicted N-terminus: His

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 47.7 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

CD抗原CD98又称4F2细胞表面抗原重链（4F2hc）、4F2重链抗原、溶质载体家族3成员2（SLC3A2）、淋巴细胞活化抗原4F2大亚基，是一种单程I型膜蛋白，属于SLC3A转运蛋白家族。SLC3A2/CD98在所有受试组织中普遍表达，在肾脏、胎盘和睾丸中检测到最高水平，在胸腺中检测到最低水平。SLC3A2/CD98是轻链氨基酸转运蛋白功能所必需的，也参与苯丙氨酸、酪氨酸、亮氨酸、精氨酸和色氨酸等大中性氨基酸的非钠依赖性、高亲和力转运。CD98参与引导和靶向LAT1和LAT2至质膜。当与SLC7A5或SLC7A8结合时，CD98通过跨膜立体选择性运输L-亚硝基半胱氨酸（L-CNSO）参与小分子量亚硝基硫醇的细胞活性。与ICAM1一起，通过产生和传递细胞内信号来调节极化肠细胞中的LAT2转运活性。