重组人STEAP1蛋白-ACROBiosystems百普赛斯

Human STEAP1 Full Length Protein, Twin-Strep,His Tag (Detergent)

分子别名（Synonym）

STEAP1, PRSS24, STEAP

表达区间及表达系统（Source）

Human STEAP1 Full Length Protein, Twin-Strep,His Tag (ST1-H5283) is expressed from human 293 cells (HEK293). It contains AA Glu 2 - Leu 339 (Accession # Q9UHE8-1).

Predicted N-terminus: Met

蛋白结构（Molecular Characterization）

This protein carries a twin strep tag at the N-terminus and a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 44.7 kDa. The protein migrates as 38 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

This product is not suitable for cell based experiments due to cytotoxicity of Digitonin.

Digitonin is INDISPENSABLE to keep membrane protein soluble and active, under no circumastance should you remove Digitonin.

Digitonin buffer (DN-12) is sold separately and not included in protein, and please contact us if you need the buffer.

If glycerol is not compatible to your application, remove glycerol just before immediate experiment, and NEVER store glycerol-free protein solution.

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, Digitonin, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 3 months under sterile conditions.

背景（Background）

前列腺6跨膜上皮抗原1（STEAP1）是一种完整的膜蛋白，在几种人类癌症的细胞表面高度上调，使其成为治疗这些疾病的有前景的治疗靶点。它与催化NADPH依赖性铁（III）还原的三种酶（STEAP2-STEAP4）具有序列同源性。考虑到其在人类癌症中的高特异性和过表达，STEAP1如今是一种有前景的治疗靶点。