重组人4-1BB Ligand / TNFSF9蛋白-ACROBiosystems百普赛斯

Human 4-1BB Ligand / TNFSF9 (71-254) Protein, His,Flag Tag, active trimer (MALS verified)

分子别名（Synonym）

4-1BB Ligand,TNFSF9,CD137L

表达区间及表达系统（Source）

Human 4-1BB Ligand (71-254) Protein, His,Flag Tag (41L-H52D4) is expressed from human 293 cells (HEK293). It contains AA Arg 71 - Glu 254 (Accession # P41273-1).

Predicted N-terminus: His

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus, followed by a flag tag.

The protein has a calculated MW of 62.8 kDa. The protein migrates as 55-60 kDa under non-reducing (NR) condition (SDS-PAGE).

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

肿瘤坏死因子配体超家族成员9（4-1BBL）也称为4-1BB配体、CD137L或TNFSF9，它是一种与TNFRSF9结合的细胞因子。4-1BBL是4-1BB的高亲和力配体。4-1BBL诱导活化的外周血T细胞增殖。此外，4-1BBL可能在活化诱导的细胞死亡（AICD）中发挥作用。此外，4-1BBL可能在T细胞和B细胞/巨噬细胞之间的同源相互作用中发挥作用。至于疾病，4-1BBL与癌症、传染病和自身免疫性疾病有关。