普罗瑞林|T6956

Protirelin
24305-27-9

￥563.00 1瓶起订

￥749.00 10瓶起订

￥218.00 1瓶起订

￥1870.00 50瓶起订

￥497.00 5瓶起订

￥1260.00 25瓶起订

上海更新日期：2024-09-14

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 普罗瑞林

英文名称：: Protirelin

CAS号：: 24305-27-9

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

产品类别：: 抑制剂

货号：: T6956

Product Introduction

Bioactivity

名称	Protirelin
描述	Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
动物实验	Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted.
体内活性	Protirelin (TRH) 是一种神经肽，在原口动物和后口动物分化之前就已存在。Protirelin 可能原本与控制胚胎后生长和繁殖有关。研究探讨了下丘脑释放激素之一的促甲状腺激素释放激素（Protirelin, TRH）对大鼠体温的影响。通过腹腔注射1, 5, 10和20 mg/kg的Protirelin给体重在200-250 g的雄性Wistar大鼠，结果显示Protirelin 能够依剂量暂时提高体温。在注射了20 mg/kg Protirelin的甲状腺切除大鼠中，相较于假手术动物的显著高热反应，这些大鼠未显示出体温上升。当前结果暗示甲状腺激素的释放可能参与了Protirelin的高热作用。
存储条件	keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	Ethanol : 67 mg/mL (184.9 mM) DMSO : 67 mg/mL (184.9 mM) H2O : 66 mg/mL (182.1 mM)
关键字	THR \| Endogenous Metabolite \| Inhibitor \| Protirelin \| Thyroid Hormone Receptor \| inhibit
相关产品	Formamide \| Oleamide \| Guanidine hydrochloride \| Naringin \| Daidzein \| Glycerol \| Sucrose \| Ferulic Acid \| Thymidine \| Fumaric acid
相关库	Ro5类药天然产物库

普罗瑞林|||Lopremone|||pGlu-His-Pro-NH2|||Synthetic thyrotropin-releasing hormone|||Thyroliberin|||TRH|||TRF

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子