重组人CD200 / OX-2蛋白-ACROBiosystems百普赛斯

Human CD200 / OX-2 Protein, His Tag

分子别名（Synonym）

CD200,MOX1,MOX2,MRC,OX-2,My033

表达区间及表达系统（Source）

Human CD200, His Tag (OX2-H5228) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gly 232 (Accession # AAH22522).

Predicted N-terminus: Gln 31

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 23.3 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>98% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

CD200也被称为OX-2膜糖蛋白（OX-2），是一种1型膜糖蛋白，含有两个免疫球蛋白结构域（1个Ig样C2型（免疫球蛋白样）结构域和Ig样V型（免疫蛋白样）功能域），因此属于免疫球蛋白超家族。CD200/OX-2在多种细胞类型中广泛表达。CD200与主要在髓系细胞上表达的结构相关受体（CD200R）相互作用，参与巨噬细胞和肥大细胞功能的调节。OX-2/CD200和CD200R通过其各自的N-末端Ig样结构域结合。CD200在预防移植物排斥反应、自身免疫性疾病和自然流产方面也起着重要作用。