黄腐醇|T3342

Xanthohumol
6754-58-1

￥248.00 1瓶起订

￥913.00 10瓶起订

￥3970.00 100瓶起订

￥2720.00 50瓶起订

￥1830.00 25瓶起订

￥8460.00 500瓶起订

￥638.00 1瓶起订

￥578.00 5瓶起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

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邮箱：marketing@targetmol.com

产品详情:

中文名称：: 黄腐醇

英文名称：: Xanthohumol

CAS号：: 6754-58-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.18%

产品类别：: 抑制剂

货号：: T3342

Product Introduction

Bioactivity

名称	Xanthohumol
描述	Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
细胞实验	HL-60 cells are maintained in RPMI 1640 supplemented with 10% FBS at 37°C in a 5% CO2 atmosphere. Log-phase cells with a population doubling time of 14–16 h are used for experiments. Serial 2-fold dilutions of compounds (dissolved in DMSO, final concentration 0.1%) in a final concentration range of 0.2–12.5 μM are prepared in 24-well plates using 1 ml of RPMI/well. Control wells obtain the same amount of solvent. Subsequently, 1 ml of the cell suspension is added to the wells. After 96 h, the experiment is evaluated. Cell numbers are counted using a Casy 1 TTC flow-cytometer. The proliferation of treated cells is expressed as a percentage in comparison with the solvent control.(Only for Reference)
激酶实验	Inhibition of Cox Activity: Inhibition of Cox-1 activity is measured by monitoring oxygen consumption during the conversion of arachidonic acid to PGs using a Clark-type O2-electrode. The reaction mixture contains ～0.2 units Cox-1 in 100 μL of microsome fraction derived from ram seminal vesicles as a crude source of Cox-1 (specific activity 0.2–1 units/mg protein) or 0.23 units of recombinant human Cox-2 (specific activity 43 units/mg protein). For calculation, the rate of O2 consumption is compared with a DMSO control (100% activity). Piroxicam, a nonsteroidal anti-inflammatory drug, is used as positive inhibitory substance for Cox-1 activity with an IC50 of 0.35 ± 0.05 μM (n = 2). Alternatively, nimesulide, a Cox-2 specific inhibitor, inhibits Cox-2 activity by 52 ± 5.7% (n = 2) at a concentration of 50 μM.
体外活性	Xanthohumol抑制小鼠肝癌细胞培养中的Cyp1A活性并诱导QR活性。Xanthohumol清除活性氧物种，抑制超氧阴离子自由基和一氧化氮的产生。此外，Xanthohumol通过抑制DNA合成、诱导细胞周期在S期停滞、凋亡及细胞分化来阻止癌症的发生。[1] Xanthohumol还显示出强大的抗HIV-1活性。[2]
体内活性	在CETP-Tg小鼠中，黄腐酚（p.o.）阻止胆固醇积聚导致动脉粥样硬化。[3] 在TRAMP小鼠中，黄腐酚（p.o.）促成尿生殖道（UG）平均重量下降, 延缓高级肿瘤进展并抑制低分化前列腺癌的生长。[4]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	Ethanol : 35.4 mg/mL (100 mM) DMSO : 5.63 mg/mL (15.87 mM), Sonication is recommended.
关键字	HSV \| Xanthohumol \| Diglyceride acyltransferase \| Influenza Virus \| mono- acylglycerol acyltransferase \| Cyclooxygenase \| inhibit \| Cytomegalovirus \| acyl-CoA:cholesterol acyltransferase \| Apoptosis \| Herpes simplex virus \| Acyltransferase \| Diacylglycerol acyltransferase \| Inhibitor \| CMV \| COX
相关产品	Oxyresveratrol \| Crystal Violet \| Metronidazole \| 5-Fluorouracil \| Curcumin \| Stavudine \| Tributyrin \| Dextran sulfate sodium salt (MW 4500-5500) \| L-Ascorbic acid \| Sodium 4-phenylbutyrate
相关库	抑制剂库 \| 经典已知活性库 \| 抗癌活性化合物库 \| 已知活性化合物库 \| 中药单体化合物库 \| 天然产物库 \| 抗病毒中药单体化合物库 \| 中药抗炎分子库 \| 高通量筛选天然产物库 \| 抗癌药物库

Xanthohumol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子