重组人CTGF蛋白-ACROBiosystems百普赛斯

Human CTGF / CCN2 Protein, His Tag

分子别名（Synonym）

CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

表达区间及表达系统（Source）

Human CTGF, His Tag (CTF-H52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Ala 349 (Accession # Q5M8T4-1).

Predicted N-terminus: Gln 27

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 37.4 kDa. The protein migrates as 36-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Potassium glutamate and Arginine, pH7.0 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

结缔组织生长因子（CTGF），也称为CCN2，是模块化基质细胞蛋白CCN（CCN1-6）家族的成员。与其他CCN蛋白一样，成熟的人CTGF由IGF结合蛋白结构域、vWF-C结构域、TSP-1结构域和半胱氨酸结肝素结合结构域组成。CTGF促进软骨细胞的增殖和分化。在许多细胞类型中介导肝素和二价阳离子依赖性细胞粘附，包括成纤维细胞、肌成纤维细胞，内皮细胞和上皮细胞。增强成纤维细胞生长因子诱导的DNA合成。CCN2在体内的功能分析主要集中在其作为多种纤维化疾病中过量ECM合成的介质的关键作用上。