重组人TDP-43蛋白-ACROBiosystems百普赛斯

Human TDP-43 Protein, His Tag

分子别名（Synonym）

TAR DNA-binding protein 43

表达区间及表达系统（Source）

Human TDP-43, His Tag (TD3-H5145) is expressed from E. coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1).

Predicted N-terminus: Met

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 46.8 kDa. The protein migrates as 54-56 kDa under reducing (R) condition (SDS-PAGE).

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 500 mM NaCl, 0.4 M Arginine, pH8.0 with glycerol as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 12 months under sterile conditions.

背景（Background）

TDP-43是一种分子量为43KDa的反式反应（TAR）-D结合蛋白，由位于1号染色体上的TARDBP基因编码。它是一种R/D结合蛋白，在结构上类似于典型的hnRNP蛋白家族成员。参与转录调控和R加工。它与散发性和家族性肌萎缩侧索硬化症和额颞叶变性有关。TDP-43主要是核的，但在病理条件下会转移到细胞质中。TDP-43蛋白病的主要标志是细胞质积累、磷酸化、泛素化和截断。