重组人IL-5蛋白-ACROBiosystems百普赛斯

Human IL-5 Protein, His Tag

分子别名（Synonym）

IL-5,TRF,IL5,Interleukin-5

表达区间及表达系统（Source）

Human IL-5 Protein, His Tag (IL5-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ile 20 - Ser 134 (Accession # P05113-1).

Predicted N-terminus: His

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 15.0 kDa. The protein migrates as 18-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

无菌（Sterility）

Negative

支原体（Mycoplasma）

Negative.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

白细胞介素5（IL-5）是由2型T辅助细胞和肥大细胞产生的白细胞介蛋白。IL-5是一种长115个氨基酸（在人类中为133个氨基酸）的TH2细胞因子，是造血家族的一部分。与该细胞因子家族的其他成员（即白细胞介素3和GM-CSF）不同，这种活性形式的糖蛋白是同二聚体。白细胞介素-5长期以来与包括过敏性鼻炎和哮喘在内的几种过敏性疾病的病因有关，其中观察到循环、气道组织和诱导痰嗜酸性粒细胞的数量大幅增加。鉴于嗜酸性粒细胞的高度一致性，特别是过敏性哮喘的病理学，人们普遍推测嗜酸性粒血球在这种疾病的病理学中起着重要作用。靶向IL-5的药物是美珠单抗和瑞珠单抗。