重组人Annexin A5/ANXA5蛋白-ACROBiosystems百普赛斯

Human Annexin A5 Protein, Tag Free

分子别名（Synonym）

ANXA5,ANX5,ENX2,PP4,Annexin V,Annexin A5

表达区间及表达系统（Source）

Human ANXA5, Tag Free (AN5-H5118) is expressed from E. coli cells. It contains AA Met 1 - Asp 320 (Accession # P08758-1).

Predicted N-terminus: Met 1

蛋白结构（Molecular Characterization）

This protein carries no "tag".

The protein has a calculated MW of 35.9 kDa. The protein migrates as 33-35 kDa under reducing (R) condition (SDS-PAGE).

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>98% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

Annexin A5是一种磷脂结合蛋白，在钙的存在下以高亲和力和选择性结合PS。PS主要位于面向细胞质的膜小叶中。然而，最近的研究结果表明，每种细胞类型都有在其细胞表面暴露PS的分子机制。这种机制在细胞凋亡过程中被激活。一旦PS暴露在细胞表面，它就会表现出促凝和促炎活性。Annexin A5会与PS暴露的凋亡细胞结合，并能抑制垂死细胞的促凝和促炎活性。Annexin A5也被确定为凝血级联中的一种抗凝蛋白，作为凝血酶原激活的抑制剂。Annexin A5抗体的存在与系统性红斑狼疮（SLE）、复发性自然流产和系统性硬化症（SSc）有关。