重组人CD209蛋白-ACROBiosystems百普赛斯

Human CD209 / DC-SIGN Protein, His Tag

分子别名（Synonym）

DC-SIGN,CD209,DC-SIGN1,CLEC4L

表达区间及表达系统（Source）

Human CD209, His Tag (CD9-H5246) is expressed from human 293 cells (HEK293). It contains AA Gln 59 - Ala 404 (Accession # Q9NNX6-1).

Predicted N-terminus: His

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 41.3 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

CD209也被称为CLEC4L、DC-SIGN和CD209抗原。病原体识别受体在未成熟树突状细胞（DC）表面表达，参与初级免疫反应的启动。在DC上，它是ICAM2和ICAM3的高亲和力受体，通过与甘露糖样碳水化合物结合。可作为DC滚动受体，通过结合内皮ICAM2介导DC前体从血液到组织的跨内皮迁移。似乎通过在DC和T细胞之间形成的免疫突触中与T细胞上的ICAM3结合来调节DC诱导的T细胞增殖。