重组人血小板生成素（TPO）蛋白-ACROBiosystems百普赛斯

Human Thrombopoietin / TPO Protein, Tag Free

分子别名（Synonym）

THPO,MGC163194,MGDF,MKCSF,ML,MPLLG,TPO,THCYT1

表达区间及表达系统（Source）

Human Thrombopoietin Protein, Tag Free (THN-H5214) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Gly 353 (Accession # P40225-1).

蛋白结构（Molecular Characterization）

This protein carries no "tag".

The protein has a calculated MW of 35.6 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

无菌（Sterility）

Negative

支原体（Mycoplasma）

Negative.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

血小板生成素（TPO）是一种332个氨基酸的糖蛋白，主要在肝脏中产生，是血小板产生的主要生理调节因子。TPO结合TPO受体，激活JAK和STAT通路，从而刺激巨核细胞生长和血小板生成。此外，进一步的研究发现，血小板生成素是促进骨髓消融后造血反弹的关键细胞因子，其转录物由多种细胞来源表达。